Path Is Found for the Spread of Alzheimer’s

Alzheimer’s disease seems to spread like an infection from brain cell to brain cell, two new studies in mice have found. But instead of viruses or bacteria, what is being spread is a distorted protein known as tau.

The surprising finding answers a longstanding question and has immediate implications for developing treatments, researchers said. And they suspect that other degenerative brain diseases like Parkinson’s may spread in a similar way.

Alzheimer’s researchers have long known that dying, tau-filled cells first emerge in a small area of the brain where memories are made and stored. The disease then slowly moves outward to larger areas that involve remembering and reasoning.

But for more than a quarter-century, researchers have been unable to decide between two explanations. One is that the spread may mean that the disease is transmitted from neuron to neuron, perhaps along the paths that nerve cells use to communicate with one another. Or it could simply mean that some brain areas are more resilient than others and resist the disease longer.

The new studies provide an answer. And they indicate it may be possible to bring Alzheimer’s disease to an abrupt halt early on by preventing cell-to-cell transmission, perhaps with an antibody that blocks tau.

by Gina Kolata, NY Times |  Read more:
Photo: Chang W. Lee

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Die Antwoord

The Brilliant Weirdness of Die Antwoord, NY Times |  Read more:

John Baldessari
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Are Women Better at Living Alone?

Earlier this month, divorcee Dominique Browning published an essay in the New York Times positing a gender gap in the talent for living alone. She and her single female neighbors, she wrote, relish the freedom to eat at odd hours and monopolize the bed, while men are indifferent to these perks. Nesting at home, she went on to assert, women feel safe. “Men,” though, “are hard-wired to feel danger all the time … Being alone feels dangerous to a man.”

These generalizations incensed commenters and bloggers, one of whom offered this summary: “Binary gender norms are alive and thriving, except the roles have reversed (sort of).” But according to sociological research, Browning wasn’t entirely off the mark. On average, women may be better suited to solitary habitation than men, at least past a certain age. It’s not, however, because men don’t love to eat Cheerios for dinner and hog the bed. Nor is it that women are more self-sufficient or inclined to solitude. On the contrary: Women are more likely to have strong social networks, which enable them to live alone without being alone. Men are more at risk of withdrawing into isolation that, at the extremes, can be miserable and indeed dangerous.

The contrast emerges clearly in Eric Klinenberg’s new book, Going Solo: The Extraordinary Rise and Surprising Appeal of Living Alone. And it matters because the people in question are hardly a negligible demographic. Though they may not realize it, they’re part of a major societal shift. In 1950, Klinenberg reports, 4 million American adults lived alone, which accounted for 9 percent of households. Today, that number is 31 million, a whopping 28 percent of all households.

by Rebecca Tuhus-Dubrow, Slate |  Read more:
Illustration by Rob Donnelly

Making Circumcisions Easier

The day of the assembly-line circumcision is drawing closer.

Now that three studies have shown that circumcising adult heterosexual men is one of the most effective “vaccines” against AIDS — reducing the chances of infection by 60 percent or more — public health experts are struggling to find ways to make the process faster, cheaper and safer.

 

The goal is to circumcise 20 million African men by 2015, but only about 600,000 have had the operation thus far. Even a skilled surgeon takes about 15 minutes, most African countries are desperately short of surgeons, and there is no Mohels Without Borders.

So donors are pinning their hopes on several devices now being tested to speed things up.

Dr. Stefano Bertozzi, director of H.I.V. for the Bill and Melinda Gates Foundation, said it had its eyes on two, named PrePex and the Shang Ring, and was supporting efforts by the World Health Organization to evaluate them.

Circumcision is believe to protect heterosexual men because the foreskin has many Langerhans cells, which pick up viruses and “present” them to the immune system — which H.I.V. attacks.

PrePex, invented in 2009 by four Israelis after one of them, a urologist, heard an appeal for doctors to do circumcisions in Africa, was approved by the Food and Drug Administration three weeks ago. The W.H.O. will make a decision on it soon, said Mitchell Warren, an AIDS-prevention expert who closely follows the process.

From the initial safety studies done so far, PrePex is clearly faster, less painful and more bloodless than any of its current rivals. And it relies on the simplest and least-threatening technology — a rubber band. 

by Donald G. McNeil, Jr., NY Times |  Read more:

What's Wrong With the Teenage Mind?

"What was he thinking?" It's the familiar cry of bewildered parents trying to understand why their teenagers act the way they do.

How does the boy who can thoughtfully explain the reasons never to drink and drive end up in a drunken crash? Why does the girl who knows all about birth control find herself pregnant by a boy she doesn't even like? What happened to the gifted, imaginative child who excelled through high school but then dropped out of college, drifted from job to job and now lives in his parents' basement?

If you think of the teenage brain as a car, today's adolescents acquire an accelerator a long time before they can steer and brake.

Adolescence has always been troubled, but for reasons that are somewhat mysterious, puberty is now kicking in at an earlier and earlier age. A leading theory points to changes in energy balance as children eat more and move less.

At the same time, first with the industrial revolution and then even more dramatically with the information revolution, children have come to take on adult roles later and later. Five hundred years ago, Shakespeare knew that the emotionally intense combination of teenage sexuality and peer-induced risk could be tragic—witness "Romeo and Juliet." But, on the other hand, if not for fate, 13-year-old Juliet would have become a wife and mother within a year or two.

Our Juliets (as parents longing for grandchildren will recognize with a sigh) may experience the tumult of love for 20 years before they settle down into motherhood. And our Romeos may be poetic lunatics under the influence of Queen Mab until they are well into graduate school.

What happens when children reach puberty earlier and adulthood later? The answer is: a good deal of teenage weirdness. Fortunately, developmental psychologists and neuroscientists are starting to explain the foundations of that weirdness.

The crucial new idea is that there are two different neural and psychological systems that interact to turn children into adults. Over the past two centuries, and even more over the past generation, the developmental timing of these two systems has changed. That, in turn, has profoundly changed adolescence and produced new kinds of adolescent woe. The big question for anyone who deals with young people today is how we can go about bringing these cogs of the teenage mind into sync once again.

by Alison Gopnik, WSJ |  Read more:
Illustration: Harry Campbell

The Wandering Gene and the Indian Princess

The Wandering Gene and the Indian Princess: Race, Religion and DNA spans continents and millennia but takes place largely in Colorado's barren and impoverished San Luis Valley, which, author Jeff Wheelwright notes drily, is "not a place you would expect to find a flare-up of Jewish consciousness." But the San Luis Valley is home to the Medinas, a large Hispano family of Spanish and Native American descent, and many of them have tested positive for the BRCA1.185delAG gene, the breast cancer mutation considered to be unambiguous evidence of Jewish ancestry.

The heart of Wheelwright's alternately fascinating and painful book is Shonnie Medina, who was diagnosed with aggressive breast cancer at age twenty-six and dead by twenty-eight. What fascinates is the author's account of how the Jewish marker first came to be and how it eventually showed up among the Catholics of the American Southwest. Scientists believe that the mutation, discovered in the mid-1990s, is 2,500 years old and that it entered the Israelite gene pool via a single founder. (Unlike recessive genes like those that cause the deadly Tay-Sachs, a rare genetic disease affecting Jews, this mutation acts alone, requiring only one parent to pass it down.) Wheelwright, a science journalist whose previous books were about the Exxon Valdez oil spill and illnesses afflicting Gulf War veterans, explains that in a bitter twist, some of the early Israelite strategies to survive in the face of oppression, including preserving "sacred separateness" and "blood purity," led to genetic isolation and the concentration of the mutation. While 1 in 100 Ashkenazi Jews are thought to be carriers of 185delAG, it likely came to the San Luis Valley by way of Sephardic Jews who colonized what was then New Spain after being forced to convert to Catholicism during the Spanish Inquisition, beginning in the late fifteenth century.

The painful part of the book, of course, concerns Shonnie, whose DNA brought her toward her terrible fate but whose culture and temperament finished her off. "Marginal medicine" and "marginal religion," Wheelwright writes, "swirl about the story of Shonnie Medina like two furies." She and many of her relatives abandoned Catholicism and became Jehovah's Witnesses in the 1980s. Shonnie was passionate about door-to-door evangelizing, and the booklet she carried with her on her home visits equated original sin to "a terrible inherited disease from which no one can escape." Wheelwright suggests that the Witnesses' apocalyptic beliefs and distrust of secular society (Shonnie's father, Joseph, eschewed banks, instead burying cash in jars spread all over his property) contributed to the young woman's decision to refuse surgery and chemotherapy. Vanity also played a role -- she couldn't accept the prospect of a mastectomy. Instead, she traveled five times to Tijuana for specious herbal therapies before her death in 1999.

As part of his research, Wheelwright spent considerable time with the extended Medina clan. He sat in on a Sunday afternoon session with a genetic counselor held at Shonnie's parents' restaurant in 2007; the counselor drove in from Colorado Springs to explain the science behind the mutation and to urge the gathered family members to undergo DNA testing. Two years later, the restaurant again played host, this time to the Hispano DNA Project, which, led by the head of the Human Genetics Program at New York University, collected blood samples from locals in an effort to amass more information about their genetic ancestry. By then the possibility of a "crypto-Jewish" community in the Valley had aroused interest from academics and the press. While some Hispanos in the area were skeptical, others, including some distant relatives of Shonnie's, began to plumb their pasts, recalling grandparents quietly lighting candles on Friday nights or avoiding pork.

by Barbara Spindel, Barnes and Noble Review |  Read more:

Water Lily ~ Jim Wehtje
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America’s Confessor

Answering night-time calls at a suicide hotline in Washington DC some years ago, Frank Warren found himself using The Voice. Addressing callers’ problems and telling them where they might seek help, he noticed, was not nearly so important as adopting a certain tone: soothing, hypnotic, passive.

Nowadays, Warren regularly speaks before hundreds of people; he says he sometimes slips into The Voice at these public events, but from what I can tell he seems to talk this way all the time. Whether he is discussing one person’s trouble tuning in to a radio station, or another’s difficulty with childhood sexual abuse, he projects relentless and unflappable sympathy.

With narrow shoulders, grey hair, glasses and a shy smile, Warren, aged 47, looks like an extra from The Office—you can imagine him trying to fix a photocopier. He also bears a resemblance to Dr Drew, America’s most famous television therapist, and like Dr Drew, Warren has risen to prominence by providing a forum where people can air their most closely held (and at times shocking) secrets. Warren has become America’s secular confessor. The question is whether so many people should be entrusting him with their most private thoughts.

Back in 2004, Warren had a small business that managed medical documents and he was bored with it. To amuse himself in his spare time he devised a little project, inspired by a dream he’d had on holiday in Paris the year before. He printed a batch of postcards with brief instructions typed on them: write on a postcard a secret that you’ve never told anyone, design the card however you like, and send it anonymously to the address provided—Warren’s home in Maryland. Warren then handed out these postcards on the streets of Washington, DC and also tucked them into books in shops.

There was an immediate and extraordinary response. The postcards soon began to pour in—and when he launched PostSecret.com on 1st January 2005, the online traffic was heavy. He used the free, bare-bones Google blogging service for amateurs that he still employs today. An armload of web awards and a spate of press attention further boosted the site’s profile. When Warren sits down to pick the 20 postcards that he posts online each Sunday, he is often choosing from a week’s total of more than 1,000, many of which are intricate works of homespun art.

Warren’s house is in a well-kept, upmarket development in Germantown, about an hour’s drive from Washington DC where the suburbs give way to farmland. The postwoman who delivers to his address tells me with a laugh that at least working the route gives her job security. Her confidence is well founded. Independent data that Warren showed me reported 1.7m unique visitors to his site per week and the hit counter on the website has registered more than half a billion visits. There are now French, German, Portuguese, Spanish and Chinese versions of the site, some of which are unauthorised. PostSecretUK launched two years ago; it is not affiliated with the original site but credits it as its inspiration.

PostSecret.com provides readers with small, potent doses of humour, sadness and intrigue. “I would rather be hit than ignored,” says one. “I stare at my cleavage when I walk down stairs.” “My mom puts a star on the calendar for every day I haven’t cut myself. I don’t deserve 5 of those stars.” “Is it wrong to thank God every day for the man I’m having an affair with?” “He said my meat loaf wasn’t as good as his Mom’s. Now I put dog food in it. And SMILE when he eats it.” Next to a US Army pin, against the backdrop of an American flag: “I will feel forever guilty for leaving you just like everyone said I would.” Absurdity and heartbreak are often placed side by side, which makes the tone of the website both weird and powerful.

by Evan Hughes, Prospect |  Read more:

Where does the anti-SOPA movement go next?

The last few weeks have witnessed a remarkable convergence of conflicts over copyright: the arrest of Megaupload mastermind “Kim Dotcom” in New Zealand, an unprecedented show of unity among Internet giants such as Wikipedia and Google to fight anti-piracy legislation in Congress, and similar protests in Poland against new copyright measures.  In a world wracked by recession, war and revolution, a topic oft-dismissed by journalists as “arcane” — copyright — has surged to the top of the political agenda.

Indeed, supporters of anti-piracy legislation in Congress have confessed their ignorance of how copyright and the Internet work, saying the details were best left to the “nerds.” Lawmakers soon heard from the nerds, though, as an online insurgency spread to thwart the Stop Online Piracy Act, galvanizing opposition across the political spectrum in a novel way, from the Creative Commons left to right-wing blogs such as RedState. The campaign epitomizes a promising new turn in American politics, as critics of intellectual property law finally find an audience and, more important, the makings of a political constituency.

It was not always so, to say the least.  Advocates of stronger copyright won an almost unbroken string of legislative and political triumphs since the early 1970s. A burst of piracy in the late 1960s, stimulated by the ease of recording on magnetic tape and the appearance of bootlegs of Bob Dylan and the Beatles, prompted Congress to extend protection to sound recordings in 1971.  Thus began a continual expansion of the powers of copyright, with the term of protection extended from a maximum of 56 years to the life of the author plus 50 years in 1976, and another 20 years added in 1998.

Entertainment industries argued they needed protection.  In a deindustrializing economy, they were job creators, net exporters of American goods.  Disney reps in the early 1980s warned Congress that movie piracy would undercut jobs and tax revenue. With trademark bombast, Hollywood lobbyist Jack Valenti declared in 1982, “We are going to bleed and bleed and hemorrhage, unless this Congress at least protects one industry that is able to retrieve a surplus of trade and whose total future depends on its protection from the savagery of this machine.”  (He was lobbying against the dreaded VCR.)

Meanwhile, opponents of stronger copyright had little to offer.  Most were tape duplicators, who built their businesses on copying records and making mixtapes.  These “pirates” urged Congress and state legislatures not to extend the length of copyright or bolster the power of rights-holders, but lawmakers paid them little attention.

Only with the rise of a new generation of copyright critics in the 1990s did a credible resistance emerge.  Academics such as Lawrence Lessig, Kembrew McLeod and Siva Vaidhyanathan pointed out how excessive copyright protections allow corporate behemoths to push around small competitors while stifling creativity, such as mashups and sampling in hip-hop.

At first, this critique remained limited to a small constituency of tech activists, artists and academics.  But Duke law professor James Boyle offered a prescient diagnosis of the movement’s problems in 1997, when he urged an “environmentalism for the net.” Environmentalism became one of America’s most vital and broad-based new political movements in the late 20th century, but its influence was initially limited.  Scientists and nature lovers worried about environmental degradation, but they faced a difficult challenge persuading others that individual issues — a dam in a public park, suburban sprawl, pollution — were connected in a way that demanded broad public concern.  The idea of the environment encompassed many issues that were different but related.

Critics of copyright, Boyle suggested, needed to theorize about the public domain in the same way nature lovers conceptualized the environment. They needed a framework to explain how intellectual property affected the people as a whole, and not just the librarians, musicians or teachers who might run up against the limits of copyright.  For instance, a handful of polluters might benefit richly from easing clean air standards, while exposure to carcinogens hurts the broader population in a diffuse and indirect way.  Similarly, lawmakers were reforming copyright law at the behest of those who stood most to profit from it — entertainment industries — but at the cost of impoverishing a public domain that most people thought little about.

by Alex Sayf Cummings, Salon |  Read more:

Regrowing Scallions

If you like to cook with scallions (aka green onions or green shallots) did you know you can keep the white root ends from purchased scallions in a glass of water and they will regrow almost indefinitely?

Household weblog Homemade Serenity shares how scallion ends can regrow in in a glass of water. Just put the root ends in a glass of water and put that glass in a sunny window. After a few days you should be able to begin harvesting the green ends of the scallions. Make sure you change the water every so often and cut what you need with scissors before cooking.

You can see in the next picture how the roots grow and tangle in the cup of water. If you want to do this at home, it's simple. The next time you have green onions, don't throw away the white ends. Simply submerge them in a glass of water and place them in a sunny window. Your onions will begin to grow almost immediately and can be harvested almost indefinitely. We just use kitchen scissors to cut what we need for meals. I periodically empty out the water, rinse the roots off and give them fresh water.

Homeade Serenity via: Lifehacker

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Zainichi Funk

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Made Better in Japan

It used be that the Japanese offered idiosyncratic takes on foreign things. White bread was transformed into shokupan, a Platonic ideal of fluffiness, aerated and feather-light in a way that made Wonder Bread seem dense. Pasta was almost always spaghetti, perfectly cooked al dente, but typically doused with cream sauce and often served with spicy codfish roe. Foreign imports here took on a life of their own, becoming something completely different and utterly Japanese.

During the robust economy of the '80s, Japan's exports ruled, and the country would import the best that money could buy from the rest of the globe, including Italian chefs and French sommeliers. Which made Japan an haute bourgeoisie heaven where luxury manufacturers from the West expected skyrocketing sales forever.

But now 20-plus years of recession have killed that dream. Louis Vuitton sales are plummeting, and magnums of Dom Pérignon are no longer being uncorked at a furious pace. That doesn't mean the Japanese have turned away from the world. They've just started approaching it on their own terms, venturing abroad and returning home with increasingly more international tastes and much higher standards, realizing that the apex of bread making may not be Wonder Bread–style loaves, but pain à l'ancienne.

Japanese chefs are now cooking almost every cuisine imaginable, combining fidelity to the original with locally sourced products that complement or replace imports. When they prepare foreign foods, they're no longer asking themselves how they can make a dish more Japanese—or even more Italian, French or American. Instead they've moved on to a more profound and difficult challenge: how to make the whole dining experience better.

As a result of this quest, Japan has become the most culturally cosmopolitan country on Earth, a place where you can lunch at a bistro that serves 22 types of delicious and thoroughly Gallic terrines, shop for Ivy League–style menswear at a store that puts to shame the old-school shops of Cambridge, Massachusetts, and spend the evening sipping rare single malts in a serene space that boasts a collection of 12,000 jazz, blues and soul albums. The best of everything can be found here, and is now often made here: American-style fashion, haute French cuisine, classic cocktails, modern luxury hotels. It might seem perverse for a traveler to Tokyo to skip sukiyaki in favor of Neapolitan pizza, but just wait until he tastes that crust.

by Tom Downey, WSJ |  Read more:
Photograph by Tung Walsh

Smart Bullets

The US military is now using a rifle that reads like a science fiction novel: each bullet has a computer chip that calculates trajectory and then blows up when it is near its target, killing the enemy with shrapnel:

via The Economist

The XM25, as the new gun is known, weighs about 6kg (13lb) and fires a 25mm round. The trick is that instead of having to be aimed directly at the target, this round need only be aimed at a place in proximity to it. Once there, it explodes—just like Shrapnel’s original artillery shells—and the fragments kill the enemy. It knows when to explode because of a timed fuse. In Shrapnel’s shells this fuse was made of gunpowder. In the XM25 it is a small computer inside the bullet that monitors details of the projectile’s flight.

A handful of XM25s are now being tested in Afghanistan by the Americans. So far, they have been used on more than 200 occasions. Most of these fights ended quickly, and in America’s favour, according to Lieutenant-Colonel Shawn Lucas, who is in charge of the weapon’s field-testing programme. Indeed, the programme has been so successful that the army has ordered 36 more of the new rifles.

A new equaliser

Each rifle bullet is programmed, before it is fired, by a second computer in the rifle itself. To determine the distance to the target, the gunman shines a laser rangefinder attached to the rifle at whatever is shielding the enemy. If that enemy is in a ditch, a nearby object—a tree trunk behind or to the side of the ditch, perhaps—will do. Looking through the rifle’s telescopic sight, the gunman then estimates the distance from this object to the target. He presses a button near the trigger to add that value to (or subtract it from) the distance determined by the rangefinder.

When the round is fired, the internal computer counts the number of rotations it makes, to calculate the distance flown. The rifle’s muzzle velocity is 210 metres a second, which is the starting point for the calculation. When the computer calculates that the round has flown the requisite distance, it issues the instruction to detonate. The explosion creates a burst of shrapnel that is lethal within a radius of several metres (exact details are classified). And the whole process takes less than five seconds.

Just how the turn-counting fuse works is an even more closely guarded secret than the lethal radius—though judging by the number of failed attempts to hack into computers that might be expected to hold information about it, many people would dearly like to know. Certainly, the trick is not easy. An alternative design developed in South Korea, which clocks flight time rather than number of rotations, seems plagued by problems. Last year South Korea’s Agency of Defence Development halted production of trial versions of the K-11, as this rifle is called, and announced a redesign, following serious malfunctions.

The XM25, in contrast, appears to work well. It is accurate at ranges of up to 500 metres. That is almost as far as America’s main assault rifle, the M-16, can shoot conventional bullets with accuracy. More pertinently, it is nearly double the range of the AK-47, a rifle of Soviet design that is used by many insurgent groups. And according to Sergeant-Major Bernard McPherson, part of the XM25’s development programme in Virginia, it is receiving rave reviews from soldiers in the field.

We are moving into a world where all designed objects will be connected, and calculating: everything is potentially smart, not just our phones.

Smart coffee mugs, smart toilets, smart money, smart business cards, smart doorknobs.

via: Stowe Boyd

Hollywood Fixer Opens His Little Black Book

Straight actors who wanted to pay for sex in the 1990s had Heidi Fleiss. Gay ones during the late 1940s and beyond apparently had Scotty Bowers.

His story has floated through moviedom’s clubby senior ranks for years: Back in a more golden age of Hollywood, a guy named Scotty, a former Marine, was said to have run a type of prostitution ring for gay and bisexual men in the film industry, including A-listers like Cary Grant, George Cukor and Rock Hudson, and even arranged sexual liaisons for actresses like Vivien Leigh and Katharine Hepburn.

“Old Hollywood people who have, shall we say, known him would tell me stories,” said Matt Tyrnauer, a writer for Vanity Fair and the director of the 2008 documentary “Valentino: The Last Emperor.” “But whenever I followed up on what would obviously be a great story, I was told, ‘Oh, he’ll never talk.’ ”

Now, he’s talking.

Mr. Bowers, 88, recalls his highly unorthodox life in a ribald memoir scheduled to be published by Grove Press on Feb. 14, “Full Service: My Adventures in Hollywood and the Secret Sex Lives of the Stars.” Written with Lionel Friedberg, an award-winning producer of documentaries, it is a lurid, no-detail-too-excruciating account of a sexual Zelig who (if you believe him) trawled an X-rated underworld for over three decades without getting caught.

“I’ve kept silent all these years because I didn’t want to hurt any of these people,” Mr. Bowers said recently over lemonade on his patio in the Hollywood Hills, where he lives in a cluttered bungalow with his wife of 27 years, Lois. “And I never saw the fascination. So they liked sex how they liked it. Who cares?”

He paused for a moment to scratch his collie, Baby, behind the ears. “I don’t need the money,” he continued. “I finally said yes because I’m not getting any younger and all of my famous tricks are dead by now. The truth can’t hurt them anymore.”

Twenty-six years after Hudson’s death from AIDS and more than four decades after “Hollywood Babylon” was first published, it will come as a surprise to no one that the images the movie factories created for stars of the 1940s, ’50s and ’60s — when Mr. Bowers was most active — were just that: images. The people who fed the world strait-laced cinema like “The Philadelphia Story” and perfect-family television like “I Love Lucy” were often quite the opposite of prudish in private.

At the same time, a lot of what Mr. Bowers has to say is pretty shocking. He claims, for instance, to have set Hepburn up with “over 150 different women.” Other stories in the 286-page memoir involve Spencer Tracy, Cole Porter, the Duke and Duchess of Windsor and socialites like the publisher Alfred A. Knopf. “If you believe him, and I do, he’s like the Kinsey Reports live and in living color,” said Mr. Tyrnauer, who recently completed a deal to make a documentary about Mr. Bowers.

by Brooks Barnes, NY Times |  Read more:
Photo: Stephanie Diani

The Behavioral Sink

How do you design a utopia? In 1972, John B. Calhoun detailed the specifications of his Mortality-Inhibiting Environment for Mice: a practical utopia built in the laboratory. Every aspect of Universe 25—as this particular model was called—was pitched to cater for the well-being of its rodent residents and increase their lifespan. The Universe took the form of a tank, 101 inches square, enclosed by walls 54 inches high. The first 37 inches of wall was structured so the mice could climb up, but they were prevented from escaping by 17 inches of bare wall above. Each wall had sixteen vertical mesh tunnels—call them stairwells—soldered to it. Four horizontal corridors opened off each stairwell, each leading to four nesting boxes. That means 256 boxes in total, each capable of housing fifteen mice. There was abundant clean food, water, and nesting material. The Universe was cleaned every four to eight weeks. There were no predators, the temperature was kept at a steady 68°F, and the mice were a disease-free elite selected from the National Institutes of Health’s breeding colony. Heaven.

Four breeding pairs of mice were moved in on day one. After 104 days of upheaval as they familiarized themselves with their new world, they started to reproduce. In their fully catered paradise, the population increased exponentially, doubling every fifty-five days. Those were the good times, as the mice feasted on the fruited plain. To its members, the mouse civilization of Universe 25 must have seemed prosperous indeed. But its downfall was already certain—not just stagnation, but total and inevitable destruction.

Calhoun’s concern was the problem of abundance: overpopulation. As the name Universe 25 suggests, it was not the first time Calhoun had built a world for rodents. He had been building utopian environments for rats and mice since the 1940s, with thoroughly consistent results. Heaven always turned into hell. They were a warning, made in a postwar society already rife with alarm over the soaring population of the United States and the world. Pioneering ecologists such as William Vogt and Fairfield Osborn were cautioning that the growing population was putting pressure on food and other natural resources as early as 1948, and both published bestsellers on the subject. The issue made the cover of Time magazine in January 1960. In 1968, Paul Ehrlich published The Population Bomb, an alarmist work suggesting that the overcrowded world was about to be swept by famine and resource wars. After Ehrlich appeared on The Tonight Show with Johnny Carson in 1970, his book became a phenomenal success. By 1972, the issue reached its mainstream peak with the report of the Rockefeller Commission on US Population, which recommended that population growth be slowed or even reversed.

But Calhoun’s work was different. Vogt, Ehrlich, and the others were neo-Malthusians, arguing that population growth would cause our demise by exhausting our natural resources, leading to starvation and conflict. But there was no scarcity of food and water in Calhoun’s universe. The only thing that was in short supply was space. This was, after all, “heaven”—a title Calhoun deliberately used with pitch-black irony. The point was that crowding itself could destroy a society before famine even got a chance. In Calhoun’s heaven, hell was other mice.

So what exactly happened in Universe 25? Past day 315, population growth slowed. More than six hundred mice now lived in Universe 25, constantly rubbing shoulders on their way up and down the stairwells to eat, drink, and sleep. Mice found themselves born into a world that was more crowded every day, and there were far more mice than meaningful social roles. With more and more peers to defend against, males found it difficult and stressful to defend their territory, so they abandoned the activity. Normal social discourse within the mouse community broke down, and with it the ability of mice to form social bonds. The failures and dropouts congregated in large groups in the middle of the enclosure, their listless withdrawal occasionally interrupted by spasms and waves of pointless violence. The victims of these random attacks became attackers. Left on their own in nests subject to invasion, nursing females attacked their own young. Procreation slumped, infant abandonment and mortality soared. Lone females retreated to isolated nesting boxes on penthouse levels. Other males, a group Calhoun termed “the beautiful ones,” never sought sex and never fought—they just ate, slept, and groomed, wrapped in narcissistic introspection. Elsewhere, cannibalism, pansexualism, and violence became endemic. Mouse society had collapsed.

by Will Wiles, Cabinet |  Read more:

via: Harpers