[ed. Ian Anderson, sounding better than ever.]
Wednesday, April 17, 2013
A Different World
In the beginning, Danyelle Carter had only one thought: I'm going to die. The 7 a.m. boot camp workout class at Spelman College is a muscle-testing, lung-battering trial for even the fittest. And Carter feels no shame in admitting that for most of her young life, she has been far from fit.
Last year, Carter says, she weighed 340 pounds. She grew up in the Bahamas and South Florida, and she learned to eat and eat and eat. Her close-knit Caribbean upbringing centered on family, and family meant food: plenty of it, all the time. If a handful of rice was good, two handfuls were better. "And everything was fried, dripping with grease," she says. Carter studied hard in school, earning an associates degree from Miami Dade College and, obeying her mother's orders, took classes to swap her native lilt for her current TV-anchor diction. But being a girl, nobody expected her to run or lift weights or play a sport. Inactivity was the rule, healthy role models the exception. High school gym class? "It was kind of like, ‘Here's a basketball, and if you use if for an hour a day it will help your heart.'" When Carter arrived in Georgia in September, a walk across the impeccably kept, historically black, all-women's campus inspired dread. It gets hot in Atlanta. It's hotter when you're more than 300 pounds.
But Carter is a sister of Spelman, and the sisterhood strives to do extraordinary things. Last November, the college announced it was dropping all intercollegiate sports at the end of this academic year, the first school in a decade to leave the NCAA. True to its motto of "A Choice to Change the World," Spelman is choosing to move $1 million a year previously budgeted for varsity sports into what leaders call a "Wellness Revolution" for all students-pouring resources into exercise classes and nutrition counseling and intramurals.
Carter jumped two-footed into Spelman's young wellness program last fall before she was even enrolled. Awaiting a transfer, she wasn't officially admitted until January. That didn't stop her or Spelman from changing her life. Carter studied all the fitness and nutrition information Spelman had to offer, and even attended campus fitness classes. She tried tai chi and Zumba, and befriended the treadmill. Within a few months, she figured she was ready for some stronger medicine, so she signed up for the boot camp in January. It hurt. More than once, she remembers thinking, One more burpee, one more lunge, and my heart's giving out. It never did.
Danyelle Carter says she now weighs 220, losing more than 25 pounds since the start of the year. She runs nearly every day. Sometimes, when she's stressed out from studying at 2 a.m., she'll jog six laps-or two miles-around the Spelman Oval, past Rockefeller Hall's stained glass and the flowery alumna arch that only graduates may walk through. She swore off cake, quit eating cereal at night and leaves the candy alone. "I love tofu now," she says. And she made peace with boot camp. Even when mired in the worst part of the workout, called 21 Down-21 pushups, then 21 crunches, then 20 of each, then 19, 18, and so on, with no rest between sets-Carter reminds herself of her mantra: Pain is weakness leaving the body.
This is how revolutions are born. And Spelman's may be a link in a chain that one day leaves the NCAA, as well as the rest of our hypercompetitive, over-selective, winner-take-all interscholastic sports system, as dead as the tsar of all the Russias.
Meanwhile, Danyelle Carter might just be the student athlete of the future. A future marked not by madness, but by common sense. One where the goal is not a championship today, but lifelong play, and where the measure of success is not maximum revenue, but a minimum level of health. Spelman College is doing something remarkable. Instead of spending seven figures a year on a few dozen varsity athletes, Spelman will expand its wellness program, funding fitness for everyone on campus.
Last year, Carter says, she weighed 340 pounds. She grew up in the Bahamas and South Florida, and she learned to eat and eat and eat. Her close-knit Caribbean upbringing centered on family, and family meant food: plenty of it, all the time. If a handful of rice was good, two handfuls were better. "And everything was fried, dripping with grease," she says. Carter studied hard in school, earning an associates degree from Miami Dade College and, obeying her mother's orders, took classes to swap her native lilt for her current TV-anchor diction. But being a girl, nobody expected her to run or lift weights or play a sport. Inactivity was the rule, healthy role models the exception. High school gym class? "It was kind of like, ‘Here's a basketball, and if you use if for an hour a day it will help your heart.'" When Carter arrived in Georgia in September, a walk across the impeccably kept, historically black, all-women's campus inspired dread. It gets hot in Atlanta. It's hotter when you're more than 300 pounds.But Carter is a sister of Spelman, and the sisterhood strives to do extraordinary things. Last November, the college announced it was dropping all intercollegiate sports at the end of this academic year, the first school in a decade to leave the NCAA. True to its motto of "A Choice to Change the World," Spelman is choosing to move $1 million a year previously budgeted for varsity sports into what leaders call a "Wellness Revolution" for all students-pouring resources into exercise classes and nutrition counseling and intramurals.
Carter jumped two-footed into Spelman's young wellness program last fall before she was even enrolled. Awaiting a transfer, she wasn't officially admitted until January. That didn't stop her or Spelman from changing her life. Carter studied all the fitness and nutrition information Spelman had to offer, and even attended campus fitness classes. She tried tai chi and Zumba, and befriended the treadmill. Within a few months, she figured she was ready for some stronger medicine, so she signed up for the boot camp in January. It hurt. More than once, she remembers thinking, One more burpee, one more lunge, and my heart's giving out. It never did.
Danyelle Carter says she now weighs 220, losing more than 25 pounds since the start of the year. She runs nearly every day. Sometimes, when she's stressed out from studying at 2 a.m., she'll jog six laps-or two miles-around the Spelman Oval, past Rockefeller Hall's stained glass and the flowery alumna arch that only graduates may walk through. She swore off cake, quit eating cereal at night and leaves the candy alone. "I love tofu now," she says. And she made peace with boot camp. Even when mired in the worst part of the workout, called 21 Down-21 pushups, then 21 crunches, then 20 of each, then 19, 18, and so on, with no rest between sets-Carter reminds herself of her mantra: Pain is weakness leaving the body.
This is how revolutions are born. And Spelman's may be a link in a chain that one day leaves the NCAA, as well as the rest of our hypercompetitive, over-selective, winner-take-all interscholastic sports system, as dead as the tsar of all the Russias.
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Our great nation was just inundated with the Caligula-worthy circus that is the NCAA Division I men's basketball tournament. College kids who won't see a classroom for weeks perform hard, physical labor (for free, at least as far as the IRS knows) on behalf of an American audience that doesn't give a rat's ass whether players can read so long as they convert some timely threes, cover the spread and bust someone else's bracket. The tournament epitomizes what our century-old interscholastic athletics system is all about. March Madness-a tiny, televised group of elites moving at high speeds to entertain great, couch-clinging masses that don't move at all-is the way sports lives now.Meanwhile, Danyelle Carter might just be the student athlete of the future. A future marked not by madness, but by common sense. One where the goal is not a championship today, but lifelong play, and where the measure of success is not maximum revenue, but a minimum level of health. Spelman College is doing something remarkable. Instead of spending seven figures a year on a few dozen varsity athletes, Spelman will expand its wellness program, funding fitness for everyone on campus.
by Luke Cyphers, SB Nation | Read more:
Photo: Getty Images
Dan Loeb Simultaneously Solicits, Betrays Pension Funds
There's confidence. There's chutzpah. And then there's Dan Loeb, hedge fund king extraordinaire and head of Third Point Capital, who's getting set to claim the World Heavyweight Championship of Balls.
On April 18, Loeb will speak before the Council of Institutional Investors, a nonprofit association of pension funds, endowments, employee benefit funds, and foundations with collective assets of over $3 trillion. The CII is an umbrella group that represents the institutions who manage the retirement and benefit funds of public and corporate employees all over America – from bricklayers to Teamsters to teachers to employees of Colgate, the Gap and Johnson and Johnson.
Loeb is going to be, in essence, pitching his services to these institutional investors. He already manages the money for several public funds, including the Ohio Public Employees' Retirement System, the New Jersey State Investment Council, the Sacramento County Employees' Retirement System, and the City of Danbury Retirement System. To give you an idea of the scale, New Jersey alone has $100 million invested with one of Loeb's funds.
When he comes to speak at CII, Lobe will almost certainly be seeking new clients. There will be some serious whales in these waters: For instance, CalSTRS, the California State Teachers' Retirement System, will definitely be represented (Anne Sheehan, the director of corporate governance for CalSTRS, will be moderating Loeb's panel).
But here's the catch. Dan Loeb, who isn't known as the biggest hedge-fund asshole still working on Wall Street (only because Stevie Cohen hasn't been arrested yet), is on the board and co-founder of a group called Students First New York. And Students First has been one of the leading advocates pushing for states to abandon defined benefit plans – packages which guarantee certain retirement benefits for public workers like teachers – in favor of defined contribution plans, where the benefits are not guaranteed.
In other words, Loeb has been soliciting the retirement money of public workers, then turning right around and lobbying for those same workers to lose their benefits. He's essentially asking workers to pay for their own disenfranchisement (with Loeb getting his two-and-twenty cut, or whatever obscene percentage of their retirement monies he will charge as a fee). If that isn't the very definition of balls, I don't know what is.
It's one thing for a group like Students First to have an opinion about defined benefit plans in general, to say, as they have, that "today's district pensions and other benefits are not sustainable and contribute to a looming fiscal crisis." But it's another thing for a Vice President of Students First like Rebecca Sibilia to tweet the following just a few weeks before one of its board members asks for money from a fund like CalSTRS:
Not long ago, the American Federation of Teachers got wind of Loeb's association with Students First and their lobbying efforts, and confronted him about it, leading to a somewhat incredible correspondence, the details of which I'll get to in a moment. But first, a little background on Loeb.
On April 18, Loeb will speak before the Council of Institutional Investors, a nonprofit association of pension funds, endowments, employee benefit funds, and foundations with collective assets of over $3 trillion. The CII is an umbrella group that represents the institutions who manage the retirement and benefit funds of public and corporate employees all over America – from bricklayers to Teamsters to teachers to employees of Colgate, the Gap and Johnson and Johnson.Loeb is going to be, in essence, pitching his services to these institutional investors. He already manages the money for several public funds, including the Ohio Public Employees' Retirement System, the New Jersey State Investment Council, the Sacramento County Employees' Retirement System, and the City of Danbury Retirement System. To give you an idea of the scale, New Jersey alone has $100 million invested with one of Loeb's funds.
When he comes to speak at CII, Lobe will almost certainly be seeking new clients. There will be some serious whales in these waters: For instance, CalSTRS, the California State Teachers' Retirement System, will definitely be represented (Anne Sheehan, the director of corporate governance for CalSTRS, will be moderating Loeb's panel).
But here's the catch. Dan Loeb, who isn't known as the biggest hedge-fund asshole still working on Wall Street (only because Stevie Cohen hasn't been arrested yet), is on the board and co-founder of a group called Students First New York. And Students First has been one of the leading advocates pushing for states to abandon defined benefit plans – packages which guarantee certain retirement benefits for public workers like teachers – in favor of defined contribution plans, where the benefits are not guaranteed.
In other words, Loeb has been soliciting the retirement money of public workers, then turning right around and lobbying for those same workers to lose their benefits. He's essentially asking workers to pay for their own disenfranchisement (with Loeb getting his two-and-twenty cut, or whatever obscene percentage of their retirement monies he will charge as a fee). If that isn't the very definition of balls, I don't know what is.
It's one thing for a group like Students First to have an opinion about defined benefit plans in general, to say, as they have, that "today's district pensions and other benefits are not sustainable and contribute to a looming fiscal crisis." But it's another thing for a Vice President of Students First like Rebecca Sibilia to tweet the following just a few weeks before one of its board members asks for money from a fund like CalSTRS:
Outdated & underfunded #pension systems like CALSTERS break promises to #teachers#edreform #thinkED http://huff.to/15vdALJ via @HuffPostEduThat's a hell of a sales pitch for Loeb to be making: "I belong to an organization that thinks you're all dinosaurs. Now give me a hundred million dollars."
Not long ago, the American Federation of Teachers got wind of Loeb's association with Students First and their lobbying efforts, and confronted him about it, leading to a somewhat incredible correspondence, the details of which I'll get to in a moment. But first, a little background on Loeb.
by Matt Taibbi, Rolling Stone | Read more:
Photo: Simon Dawson/Bloomberg via Getty ImagesMental Disorder or Neurodiversity?
One of the most famous stories of H. G. Wells, “The Country of the Blind” (1904), depicts a society, enclosed in an isolated valley amid forbidding mountains, in which a strange and persistent epidemic has rendered its members blind from birth. Their whole culture is reshaped around this difference: their notion of beauty depends on the feel rather than the look of a face; no windows adorn their houses; they work at night, when it is cool, and sleep during the day, when it is hot. A mountain climber named Nunez stumbles upon this community and hopes that he will rule over it: “In the Country of the Blind the One-Eyed Man is King,” he repeats to himself. Yet he comes to find that his ability to see is not an asset but a burden. The houses are pitch-black inside, and he loses fights to local warriors who possess extraordinary senses of touch and hearing. The blind live with no knowledge of the sense of sight, and no need for it. They consider Nunez’s eyes to be diseased, and mock his love for a beautiful woman whose face feels unattractive to them. When he finally fails to defeat them, exhausted and beaten, he gives himself up. They ask him if he still thinks he can see: “No,” he replies, “That was folly. The word means nothing — less than nothing!” They enslave him because of his apparently subhuman disability. But when they propose to remove his eyes to make him “normal,” he realizes the beauty of the mountains, the snow, the trees, the lines in the rocks, and the crispness of the sky — and he climbs a mountain, attempting to escape.
Wells’s eerie and unsettling story addresses how we understand differences that run deep into the mind and the brain. What one man thinks of as his heightened ability, another thinks of as a disability. This insight about the differences between ways of viewing the world runs back to the ancients: in Plato’s Phaedrus, Socrates discusses how insane people experience life, telling Phaedrus that madness is not “simply an evil.” Instead, “there is also a madness which is a divine gift, and the source of the chiefest blessings granted to men.” The insane, Socrates suggests, are granted a unique experience of the world, or perhaps even special access to its truths — seeing it in a prophetic or artistic way.
Today, some psychologists, journalists, and advocates explore and celebrate mental differences under the rubric of neurodiversity. The term encompasses those with Attention Deficit/Hyperactivity Disorder (ADHD), autism, schizophrenia, depression, dyslexia, and other disorders affecting the mind and brain. People living with these conditions have written books, founded websites, and started groups to explain and praise the personal worlds of those with different neurological “wiring.” The proponents of neurodiversity argue that there are positive aspects to having brains that function differently; many, therefore, prefer that we see these differences simply as differences rather than disorders. Why, they ask, should what makes them them need to be classified as a disability?
But other public figures, including many parents of affected children, focus on the difficulties and suffering brought on by these conditions. They warn of the dangers of normalizing mental disorders, potentially creating reluctance among parents to provide treatments to children — treatments that researchers are always seeking to improve. The National Institute of Mental Health, for example, has been doing extensive research on the physical and genetic causes of various mental conditions, with the aim of controlling or eliminating them.
Disagreements, then, abound. What does it mean to see and experience the world in a different way? What does it mean to be a “normal” human being? What does it mean to be abnormal, disordered, or sick? And what exactly would a cure for these disorders look like? The answers to these questions may be as difficult to know as the minds of others. Learning how properly to treat or accommodate neurological differences means seeking answers to questions such as these — challenging our ideas about “normal” human biology, the purpose of medical innovation, and the uniqueness of each human being.
Wells’s eerie and unsettling story addresses how we understand differences that run deep into the mind and the brain. What one man thinks of as his heightened ability, another thinks of as a disability. This insight about the differences between ways of viewing the world runs back to the ancients: in Plato’s Phaedrus, Socrates discusses how insane people experience life, telling Phaedrus that madness is not “simply an evil.” Instead, “there is also a madness which is a divine gift, and the source of the chiefest blessings granted to men.” The insane, Socrates suggests, are granted a unique experience of the world, or perhaps even special access to its truths — seeing it in a prophetic or artistic way.
Today, some psychologists, journalists, and advocates explore and celebrate mental differences under the rubric of neurodiversity. The term encompasses those with Attention Deficit/Hyperactivity Disorder (ADHD), autism, schizophrenia, depression, dyslexia, and other disorders affecting the mind and brain. People living with these conditions have written books, founded websites, and started groups to explain and praise the personal worlds of those with different neurological “wiring.” The proponents of neurodiversity argue that there are positive aspects to having brains that function differently; many, therefore, prefer that we see these differences simply as differences rather than disorders. Why, they ask, should what makes them them need to be classified as a disability?
But other public figures, including many parents of affected children, focus on the difficulties and suffering brought on by these conditions. They warn of the dangers of normalizing mental disorders, potentially creating reluctance among parents to provide treatments to children — treatments that researchers are always seeking to improve. The National Institute of Mental Health, for example, has been doing extensive research on the physical and genetic causes of various mental conditions, with the aim of controlling or eliminating them.
Disagreements, then, abound. What does it mean to see and experience the world in a different way? What does it mean to be a “normal” human being? What does it mean to be abnormal, disordered, or sick? And what exactly would a cure for these disorders look like? The answers to these questions may be as difficult to know as the minds of others. Learning how properly to treat or accommodate neurological differences means seeking answers to questions such as these — challenging our ideas about “normal” human biology, the purpose of medical innovation, and the uniqueness of each human being.
by Aaron Rothstein, The New Atlantis | Read more:
In the Country of the Blind ~ Alan PollackThe Boston Bombing Produces Familiar and Revealing Reactions
[ed. As Glenn mentions in his update, be sure to read Amy Davidson's chilling: The Saudi Marathon Man]
(1) The widespread compassion for yesterday's victims and the intense anger over the attacks was obviously authentic and thus good to witness. But it was really hard not to find oneself wishing that just a fraction of that compassion and anger be devoted to attacks that the US perpetrates rather than suffers. These are exactly the kinds of horrific, civilian-slaughtering attacks that the US has been bringing to countries in the Muslim world over and over and over again for the last decade, with very little attention paid. My Guardian colleague Gary Younge put this best on Twitter this morning:
One particularly illustrative example I happened to see yesterday was a re-tweet from Washington Examiner columnist David Freddoso, proclaiming:
Idea of secondary bombs designed to kill the first responders is just sick. How does anyone become that evil?"I don't disagree with that sentiment. But I'd bet a good amount of money that the person saying it - and the vast majority of other Americans - have no clue that targeting rescuers with "double-tap" attacks is precisely what the US now does with its drone program and other forms of militarism. If most Americans knew their government and military were doing this, would they react the same way as they did to yesterday's Boston attack: "Idea of secondary bombs designed to kill the first responders is just sick. How does anyone become that evil?" That's highly doubtful, and that's the point.
There's nothing wrong per se with paying more attention to tragedy and violence that happens relatively nearby and in familiar places. Whether wrong or not, it's probably human nature, or at least human instinct, to do that, and that happens all over the world. I'm not criticizing that. But one wishes that the empathy for victims and outrage over the ending of innocent human life that instantly arises when the US is targeted by this sort of violence would at least translate into similar concern when the US is perpetrating it, as it so often does (far, far more often than it is targeted by such violence).
Regardless of your views of justification and intent: whatever rage you're feeling toward the perpetrator of this Boston attack, that's the rage in sustained form that people across the world feel toward the US for killing innocent people in their countries. Whatever sadness you feel for yesterday's victims, the same level of sadness is warranted for the innocent people whose lives are ended by American bombs. However profound a loss you recognize the parents and family members of these victims to have suffered, that's the same loss experienced by victims of US violence. It's natural that it won't be felt as intensely when the victims are far away and mostly invisible, but applying these reactions to those acts of US aggression would go a long way toward better understanding what they are and the outcomes they generate.
(2) The rush, one might say the eagerness, to conclude that the attackers were Muslim was palpable and unseemly, even without any real evidence. The New York Post quickly claimed that the prime suspect was a Saudi national (while also inaccurately reporting that 12 people had been confirmed dead). The Post's insinuation of responsibility was also suggested on CNN by Former Bush Homeland Security Adviser Fran Townsend ("We know that there is one Saudi national who was wounded in the leg who is being spoken to"). Former Democratic Rep. Jane Harman went on CNN to grossly speculate that Muslim groups were behind the attack. Anti-Muslim bigots like Pam Geller predictably announced that this was "Jihad in America". Expressions of hatred for Muslims, and a desire to do violence, were then spewing forth all over Twitter (some particularly unscrupulous partisan Democrat types were identically suggesting with zero evidence that the attackers were right-wing extremists).
Obviously, it's possible that the perpetrator(s) will turn out to be Muslim, just like it's possible they will turn out to be extremist right-wing activists, or left-wing agitators, or Muslim-fearing Anders-Breivik types, or lone individuals driven by apolitical mental illness. But the rush to proclaim the guilty party to be Muslim is seen in particular over and over with such events. Recall that on the day of the 2011 Oslo massacre by a right-wing, Muslim-hating extremist, the New York Times spent virtually the entire day strongly suggesting in its headlines that an Islamic extremist group was responsible, a claim other major news outlets (including the BBC and Washington Post) then repeated as fact. The same thing happened with the 1995 Oklahoma City bombing, when most major US media outlets strongly suggested that the perpetrators were Muslims. As FAIR documented back then:
"In the wake of the explosion that destroyed the Murrah Federal Office Building, the media rushed — almost en masse — to the assumption that the bombing was the work of Muslim extremists. 'The betting here is on Middle East terrorists,' declared CBS News' Jim Stewart just hours after the blast (4/19/95). 'The fact that it was such a powerful bomb in Oklahoma City immediately drew investigators to consider deadly parallels that all have roots in the Middle East,' ABC's John McWethy proclaimed the same day.
"'It has every single earmark of the Islamic car-bombers of the Middle East,' wrote syndicated columnist Georgie Anne Geyer (Chicago Tribune, 4/21/95). 'Whatever we are doing to destroy Mideast terrorism, the chief terrorist threat against Americans, has not been working,' declared the New York Times' A.M. Rosenthal (4/21/95). The Geyer and Rosenthal columns were filed after the FBI released sketches of two suspects who looked more like Midwestern frat boys than mujahideen."This lesson is never learned because, it seems, many people don't want to learn it. Even when it turns out not to have been Muslims who perpetrated the attack but rather right-wing, white Christians, the damage from this relentless and reflexive blame-pinning endures.
by Glenn Greenwald, The Guardian | Read more:
Photograph: Stringer/ReutersMass. General Team Develops Implantable, Bioengineered Rat Kidney
The research team describes building functional replacement kidneys on the structure of donor organs from which living cells had been stripped, an approach previously used to create bioartificial hearts, lungs, and livers.
“What is unique about this approach is that the native organ’s architecture is preserved, so that the resulting graft can be transplanted just like a donor kidney and connected to the recipient’s vascular and urinary systems,” says Harald Ott, MD, PhD, of the MGH Center for Regenerative Medicine, senior author of the Nature Medicine article.
“If this technology can be scaled to human-sized grafts, patients suffering from renal failure who are currently waiting for donor kidneys or who are not transplant candidates could theoretically receive new organs derived from their own cells.”
Around 18,000 kidney transplants are performed in the U.S. each year, but 100,000 Americans with end-stage kidney disease are still waiting for a donor organ. Even those fortunate enough to receive a transplant face a lifetime of immunosuppressive drugs, which pose many health risks and cannot totally eliminate the incidence of eventual organ rejection.
Retrofitted donor organs
The approach used in this study to engineer donor organs, based on a technology that Ott discovered as a research fellow at the University of Minnesota, involves stripping the living cells from a donor organ with a detergent solution and then repopulating the collagen scaffold that remains with the appropriate cell type — in this instance human endothelial cells to replace the lining of the vascular system and kidney cells from newborn rats.
The research team first decellularized rat kidneys to confirm that the organ’s complex structures would be preserved. They also showed the technique worked on a larger scale by stripping cells from pig and human kidneys.
Making sure the appropriate cells were seeded into the correct portions of the collagen scaffold required delivering vascular cells through the renal artery and kidney cells through the ureter. Precisely adjusting the pressures of the solutions enabled the cells to be dispersed throughout the whole organs, which were then cultured in a bioreactor for up to 12 days.
The researchers first tested the repopulated organs in a device that passed blood through its vascular system and drained off any urine, which revealed evidence of limited filtering of blood, molecular activity and urine production.
Bioengineered kidneys transplanted into living rats from which one kidney had been removed began producing urine as soon as the blood supply was restored, with no evidence of bleeding or clot formation. The overall function of the regenerated organs was significantly reduced compared with that of normal, healthy kidneys, something the researchers believe may be attributed to the immaturity of the neonatal cells used to repopulate the scaffolding.
by Amara D. Angelica, Editor, Kurzweil Accelerated Intelligence | Read more:
Massachusetts General Hospital Center for Regenerative Medicine
“What is unique about this approach is that the native organ’s architecture is preserved, so that the resulting graft can be transplanted just like a donor kidney and connected to the recipient’s vascular and urinary systems,” says Harald Ott, MD, PhD, of the MGH Center for Regenerative Medicine, senior author of the Nature Medicine article.
“If this technology can be scaled to human-sized grafts, patients suffering from renal failure who are currently waiting for donor kidneys or who are not transplant candidates could theoretically receive new organs derived from their own cells.”
Around 18,000 kidney transplants are performed in the U.S. each year, but 100,000 Americans with end-stage kidney disease are still waiting for a donor organ. Even those fortunate enough to receive a transplant face a lifetime of immunosuppressive drugs, which pose many health risks and cannot totally eliminate the incidence of eventual organ rejection.
Retrofitted donor organs
The approach used in this study to engineer donor organs, based on a technology that Ott discovered as a research fellow at the University of Minnesota, involves stripping the living cells from a donor organ with a detergent solution and then repopulating the collagen scaffold that remains with the appropriate cell type — in this instance human endothelial cells to replace the lining of the vascular system and kidney cells from newborn rats.
The research team first decellularized rat kidneys to confirm that the organ’s complex structures would be preserved. They also showed the technique worked on a larger scale by stripping cells from pig and human kidneys.
Making sure the appropriate cells were seeded into the correct portions of the collagen scaffold required delivering vascular cells through the renal artery and kidney cells through the ureter. Precisely adjusting the pressures of the solutions enabled the cells to be dispersed throughout the whole organs, which were then cultured in a bioreactor for up to 12 days.
The researchers first tested the repopulated organs in a device that passed blood through its vascular system and drained off any urine, which revealed evidence of limited filtering of blood, molecular activity and urine production.
Bioengineered kidneys transplanted into living rats from which one kidney had been removed began producing urine as soon as the blood supply was restored, with no evidence of bleeding or clot formation. The overall function of the regenerated organs was significantly reduced compared with that of normal, healthy kidneys, something the researchers believe may be attributed to the immaturity of the neonatal cells used to repopulate the scaffolding.
by Amara D. Angelica, Editor, Kurzweil Accelerated Intelligence | Read more:
Massachusetts General Hospital Center for Regenerative Medicine
Tuesday, April 16, 2013
Mexican Manifesto (Fiction)
Laura and I did not make love that afternoon. In truth, we gave it a shot, but it just didn’t happen. Or, at least, that’s what I thought at the time. Now I’m not so sure. We probably did make love. That’s what Laura said, and while we were at it she introduced me to the world of public baths, which from then on, and for a very long time, I would associate with pleasure and play. The first one was, without a doubt, the best. It was called Montezuma’s Gym, and in the foyer some unknown artist had done a mural where you could see the Aztec emperor neck-deep in a pool. Around the edges, close to the monarch but much smaller, smiling men and women bathe. Everyone seems carefree except the king, who looks fixedly out of the mural, as if searching for the improbable spectator, with dark, wide-open eyes in which I often thought I glimpsed terror. The water in the pool is green. The stones are gray. In the background, you can see mountains and storm clouds.
The boy who worked at Montezuma’s Gym was an orphan, and that was his primary topic of conversation. On the third visit, we became friends. He was only eighteen, and wanted to buy a car, so he was saving everything he could: tips were scant. According to Laura, he was a little slow. I thought he was nice.
In every public bath, there tends to be a fight from time to time. We never saw or heard any there. The clients, conditioned by some unknown mechanism, respected and obeyed every word of the orphan’s instructions. Also, to be fair, there weren’t very many people, and that’s something I’ll never be able to explain, since it was a clean place, relatively modern, with individual saunas for taking steam baths, bar service in the saunas, and, above all, cheap. There, in Sauna 10, I saw Laura naked for the first time, and all I could do was smile and touch her shoulder and say I didn’t know which valve to turn to make the steam come out.
The saunas, though it might be more precise to call them private rooms, were a set of two tiny chambers connected by a glass door. In the first, there was usually a divan—an old divan reminiscent of psychoanalysis and bordellos—a folding table, and a coatrack; the second chamber was the actual steam bath, with a hot and cold shower and a bench of azulejo tiles against the wall, beneath which were hidden the tubes that released the steam. Moving from one vestibule to the next was extraordinary, especially if the steam was already so thick that we couldn’t see each other. Then we would open the door and head into the chamber with the divan, where everything was clear, and behind us, like the filaments of a dream, clouds of steam slipped by and quickly disappeared. Lying there, holding hands, we would listen or try to listen to the barely perceptible sounds of the gym while our bodies cooled. Practically freezing, submerged in silence, we would finally hear the purr welling up through the floor and the walls, the catlike whir of hot pipes and boilers that stoked the business from some secret place in the building.
One day I’ll wander around in here, Laura said. Her experience raiding public baths was greater than mine, which wasn’t saying much, considering I’d never before crossed the threshold of such an establishment. Nevertheless, she said she knew nothing of baths. Not enough. She’d gone a couple of times with X and, before X, with a guy who was twice her age and whom she always referred to with mysterious phrases. In total, she hadn’t been more than ten times, always to the same place, Montezuma’s Gym.
The boy who worked at Montezuma’s Gym was an orphan, and that was his primary topic of conversation. On the third visit, we became friends. He was only eighteen, and wanted to buy a car, so he was saving everything he could: tips were scant. According to Laura, he was a little slow. I thought he was nice.
In every public bath, there tends to be a fight from time to time. We never saw or heard any there. The clients, conditioned by some unknown mechanism, respected and obeyed every word of the orphan’s instructions. Also, to be fair, there weren’t very many people, and that’s something I’ll never be able to explain, since it was a clean place, relatively modern, with individual saunas for taking steam baths, bar service in the saunas, and, above all, cheap. There, in Sauna 10, I saw Laura naked for the first time, and all I could do was smile and touch her shoulder and say I didn’t know which valve to turn to make the steam come out.
The saunas, though it might be more precise to call them private rooms, were a set of two tiny chambers connected by a glass door. In the first, there was usually a divan—an old divan reminiscent of psychoanalysis and bordellos—a folding table, and a coatrack; the second chamber was the actual steam bath, with a hot and cold shower and a bench of azulejo tiles against the wall, beneath which were hidden the tubes that released the steam. Moving from one vestibule to the next was extraordinary, especially if the steam was already so thick that we couldn’t see each other. Then we would open the door and head into the chamber with the divan, where everything was clear, and behind us, like the filaments of a dream, clouds of steam slipped by and quickly disappeared. Lying there, holding hands, we would listen or try to listen to the barely perceptible sounds of the gym while our bodies cooled. Practically freezing, submerged in silence, we would finally hear the purr welling up through the floor and the walls, the catlike whir of hot pipes and boilers that stoked the business from some secret place in the building.
One day I’ll wander around in here, Laura said. Her experience raiding public baths was greater than mine, which wasn’t saying much, considering I’d never before crossed the threshold of such an establishment. Nevertheless, she said she knew nothing of baths. Not enough. She’d gone a couple of times with X and, before X, with a guy who was twice her age and whom she always referred to with mysterious phrases. In total, she hadn’t been more than ten times, always to the same place, Montezuma’s Gym.
Together, riding a Benelli—they were everywhere then—we attempted to visit all the baths in Mexico City, guided by an absolute eagerness that was a combination of love and play. We never succeeded. On the contrary, as we advanced the abyss opened up around us, the great black scenography of public baths. Just as the hidden face of other cities is in theatres, parks, docks, beaches, labyrinths, churches, brothels, bars, cheap cinemas, old buildings, even supermarkets, the hidden face of Mexico City could be found in the enormous web of public baths, legal, semilegal, and clandestine. Setting our course was simple at first: I asked the boy at Montezuma’s Gym to point me in the direction of some cheap baths. I got five cards and wrote the addresses of a dozen establishments on a piece of paper. These were the first. From them, our search branched off countless times. The schedules varied as much as the buildings did. We arrived at some at 10 a.m. and left at lunchtime. These, as a rule, were bright places with flaking walls, where we could sometimes hear the laughter of teen-agers and the coughing of lost and lonely men, the same men who, a little while later, having collected themselves, would get up and sing boleros. The essence of those places seemed to be limbo, a dead child’s closed eyes. They weren’t very clean, or maybe the cleaning was done later in the day. At others, we’d make our appearance at four or five in the afternoon and wouldn’t leave until dark. That was our most common schedule. The baths at that hour seemed to enjoy, or suffer from, a permanent shadow. That is, a trick shadow, a dome or a palm tree, the closest thing to a marsupial’s pouch; at first you’re grateful for it, but it ends up weighing more than a tombstone.
U.S. Practiced Torture After 9/11, Nonpartisan Review Concludes
[ed. At least now they're describing it for what it was: torture. No more beating around the bush with so-called "enhanced interogation techniques". And, speaking of beatings and bushes, in other news: George W. Bush gets a shiny new library, and continues to grow as a budding Artiste.]
A nonpartisan, independent review of interrogation and detention programs in the years after the Sept. 11, 2001, terrorist attacks concludes that “it is indisputable that the United States engaged in the practice of torture” and that the nation’s highest officials bore ultimate responsibility for it.The sweeping, 577-page report says that while brutality has occurred in every American war, there never before had been “the kind of considered and detailed discussions that occurred after 9/11 directly involving a president and his top advisers on the wisdom, propriety and legality of inflicting pain and torment on some detainees in our custody.” The study, by an 11-member panel convened by the Constitution Project, a legal research and advocacy group, is to be released on Tuesday morning.
Debate over the coercive interrogation methods used by the administration of President George W. Bush has often broken down on largely partisan lines. The Constitution Project’s task force on detainee treatment, led by two former members of Congress with experience in the executive branch — a Republican, Asa Hutchinson, and a Democrat, James R. Jones — seeks to produce a stronger national consensus on the torture question.
While the task force did not have access to classified records, it is the most ambitious independent attempt to date to assess the detention and interrogation programs. A separate 6,000-page report on the Central Intelligence Agency’s record by the Senate Intelligence Committee, based exclusively on agency records, rather than interviews, remains classified.
“As long as the debate continues, so too does the possibility that the United States could again engage in torture,” the report says.
The use of torture, the report concludes, has “no justification” and “damaged the standing of our nation, reduced our capacity to convey moral censure when necessary and potentially increased the danger to U.S. military personnel taken captive.” The task force found “no firm or persuasive evidence” that these interrogation methods produced valuable information that could not have been obtained by other means. While “a person subjected to torture might well divulge useful information,” much of the information obtained by force was not reliable, the report says.
Interrogation and abuse at the C.I.A.’s so-called black sites, the Guantánamo Bay prison in Cuba and war-zone detention centers, have been described in considerable detail by the news media and in declassified documents, though the Constitution Project report adds many new details.
It confirms a report by Human Rights Watch that one or more Libyan militants were waterboarded by the C.I.A., challenging the agency’s longtime assertion that only three Al Qaeda prisoners were subjected to the near-drowning technique. It includes a detailed account by Albert J. Shimkus Jr., then a Navy captain who ran a hospital for detainees at the Guantánamo Bay prison, of his own disillusionment when he discovered what he considered to be the unethical mistreatment of prisoners.
But the report’s main significance may be its attempt to assess what the United States government did in the years after 2001 and how it should be judged. The C.I.A. not only waterboarded prisoners, but slammed them into walls, chained them in uncomfortable positions for hours, stripped them of clothing and kept them awake for days on end.
The question of whether those methods amounted to torture is a historically and legally momentous issue that has been debated for more than a decade inside and outside the government. The Justice Department’s Office of Legal Counsel wrote a series of legal opinions from 2002 to 2005 concluding that the methods were not torture if used under strict rules; all the memos were later withdrawn. News organizations have wrestled with whether to label the brutal methods unequivocally as torture in the face of some government officials’ claims that they were not.
In addition, the United States is a signatory to the international Convention Against Torture, which requires the prompt investigation of allegations of torture and the compensation of its victims.
by Scott Shane, NY Times | Read more:
Image: George W. Bush
Monday, April 15, 2013
Thatcher, 9/11 and Boston
In the current New Republic, Geoffrey Wheatcroft, who knows whereof he speaks (he covered Mrs. Thatcher’s rise and fall for half of Fleet Street, and wrote about it in his 2005 book, “The Strange Death of Tory England”), recalls a striking instance:
On the evening of Thursday October 11, 1984, at the Conservative conference in Brighton, I was in a suite in the Grand Hotel where a small party was being held. The prime minister was sitting on a sofa nearby engaged in animated conversation, which I did not interrupt. Later on, I went elsewhere, and she went to her own room. Shortly before three in the morning, a bomb planted by the Irish Republican Army wrecked the hotel, killing five people and narrowly missing the prime minister.
She emerged in disarray, but in one piece. Later in the day, she gave a speech as scheduled, but now saying that the very fact they were still gathered there, “shocked but composed and determined, is a sign not only that this attack has failed but that all attempts to destroy democracy by terrorism will fail.” No, she wasn’t bringing harmony that day, but she was magnificent all the same.Mrs. Thatcher’s bracing, keep-calm-and-carry-on response to a terrorist outrage—one that nearly took her own life—contrasts favorably to the tsunami of fear and overreaction that engulfed the United States in the wake of the (admittedly much bloodier) attacks of 9/11. That continues to this day in such varied forms as a bloated and secretive national-security establishment, the unending shame of Guantánamo, and a cult of memorialization (the annual reading of the names of victims, the wrongheaded project of a museum at Ground Zero, etc.) that has had the ironic effect of darkly glorifying the perpetrators. There’s still a lot we don’t know about today’s gruesome explosions at the end of the Boston Marathon—the dead and injured are still being counted. But the aftereffects of the tragedy will surely test how much, if anything, we have learned about keeping calm and carrying on.
by Hendrik Hertzberg, New Yorker | Read more:
Photo: Simon Dack/Rex Features/APSteak Shows Its Muscle
I once dined with the Masai in the Serengeti. Seven thirty for eight, smart safari casual. I tiptoed up to the thorn enclosure, shook hands, smiled, talked about the weather and the flies and the children’s beadwork, admired the big lotus-bladed lion spears, and then my host said, “Shall we go through?” We went into the dining room, which was also the cattle pen, where dinner was standing with a tourniquet around its neck and a lad pulling its tail. A boy took a bow with a blunt arrow and shot a hole in the animal’s jugular vein, which spurted a river of blood dexterously into a long, bulbous gourd that had been cleaned for my benefit with cow’s urine.
After about half a pint had been tapped, the tourniquet was released, a finger of dung applied to the hole, and the steer was re-united with his mates to complain about the greed and cold hands of cooks. The dinner soup was briskly whisked with a stick to keep it from clotting, the stick was handed to a child in the way your mother gave you the cake-mix spoon, and the gourd was hospitably given to me. It was heavy. The family watched with a host’s nervous expectation. Cheers, I said weakly, and lifted it to my mouth. The smell of the disinfected pot reeked rank as I felt the blood move and lurch in the gourd’s neck like a slinking dark animal. And then, before I was ready, my mouth was full, cheeks bulging with body-heat gore the texture of custard, silky and vital and forcing open my constricted throat. I swallowed. Great visceral chugs.
Imagine what it tasted like. Just think. Because, actually, you already know. You know what warm blood straight from a bull’s heart tastes of—it tastes of steak. Not merely like steak. Not just a little meaty. But of the very finest, perfectly velvety, unctuous steak I’d ever tasted. But it isn’t the blood that tastes of steak, it’s steak that tastes of blood, and that’s all it tastes of. I never eat a sirloin now without thinking, This is good, but not quite as good as the real oozing liquid thing. My Masai dinner was, incidentally, the only steak a vegetarian could ethically eat; no animals were killed. It was organic, and it was wholly sustainable. The Masai’s cows owe their long and treasured lives to this occasional painless cupping.
We live in the steak age; marbled fatty buttock is the defining mouthful of our time. Smart cities are being stampeded by herds of restaurants devoted to cows’ arses. This is the bovine spring of red meat, and it’s not just America or the West. Around the world, communities that a generation ago rarely or never ate steak are now craving and demanding the taste of blood. In 1950 there were an estimated 720 million cows in the world. Today there are nearly one and a half billion. In America there is one cow for every three people. Think of a third of a cow—that’s what’s on your plate, and you’re not getting up until you’ve finished it.
Why have we fallen in such greedy love with beef? What does steak say to us and about us? Well, it’s manly. If food came with gender appellations, steak would definitely be at the top of the bloke column. Women can eat it, they can appreciate it, but it’s like girls chugging pints of beer and then burping. It’s a cross-gender impersonation. Steak is a high-value food that doesn’t need a chef. You don’t want some twiddly-accented, jus-dribbling, foam-flicking chef mincing about with your meat. You want a guy in a checked shirt with his sleeves rolled up forking and tonging your T-bone. Steaks even come with their own butch utensils. It’s more like engineering or Lego than cooking. It’s boy stuff. The porterhouse used to be the dining choice of a gauche out-of-towner, a man who was uncomfortable with chic urban menus and didn’t know how to order—“Oh, I’ll just have the steak. Wipe its behind and bring it to the table,” they’d say, just to let the rest of us cheese-eating sophisticates know that they weren’t intimidated hicks. Restaurants would keep steak on the menu just for them because they knew there would always be a certain sort of guy who didn’t think it was an acceptable date restaurant if he couldn’t get a New York strip. Chefs hate steaks because their reputations are left in the hands of their butchers—two cuts off the same muscle can eat quite differently.
But today steak is, if not chic, then at least modern. Steak houses used to be leathery, clubbable lounges with cartoons of dead customers on the walls and faux Victorian paintings of obese cattle, staffed by ancient, permanently enraged waiters with faces as livid as well-hung sirloin and aprons that went from nipple to ankle. Now a steak restaurant is more likely to be James Bond luxurious and internationally expensive, a setting for chiseled-jawed, silver-templed seduction and couples with multiple passports. A place for men—who might fear that their testicles would pack their bags and leave if they caught them talking about terroir or heirloom tomatoes—to have a detailed and exhaustively knowledgeable discussion about dry-aging, grass-fed versus corn-fed, and the state of Wagyu-Angus crossbreeding. Steak has become the butch foodie communion, and tellingly not just for flinty-eyed, Armani-suited leaner-than-thou businessmen, but for metrosexuals who wish to beef up their cultural testosterone.
After about half a pint had been tapped, the tourniquet was released, a finger of dung applied to the hole, and the steer was re-united with his mates to complain about the greed and cold hands of cooks. The dinner soup was briskly whisked with a stick to keep it from clotting, the stick was handed to a child in the way your mother gave you the cake-mix spoon, and the gourd was hospitably given to me. It was heavy. The family watched with a host’s nervous expectation. Cheers, I said weakly, and lifted it to my mouth. The smell of the disinfected pot reeked rank as I felt the blood move and lurch in the gourd’s neck like a slinking dark animal. And then, before I was ready, my mouth was full, cheeks bulging with body-heat gore the texture of custard, silky and vital and forcing open my constricted throat. I swallowed. Great visceral chugs.
Imagine what it tasted like. Just think. Because, actually, you already know. You know what warm blood straight from a bull’s heart tastes of—it tastes of steak. Not merely like steak. Not just a little meaty. But of the very finest, perfectly velvety, unctuous steak I’d ever tasted. But it isn’t the blood that tastes of steak, it’s steak that tastes of blood, and that’s all it tastes of. I never eat a sirloin now without thinking, This is good, but not quite as good as the real oozing liquid thing. My Masai dinner was, incidentally, the only steak a vegetarian could ethically eat; no animals were killed. It was organic, and it was wholly sustainable. The Masai’s cows owe their long and treasured lives to this occasional painless cupping.
We live in the steak age; marbled fatty buttock is the defining mouthful of our time. Smart cities are being stampeded by herds of restaurants devoted to cows’ arses. This is the bovine spring of red meat, and it’s not just America or the West. Around the world, communities that a generation ago rarely or never ate steak are now craving and demanding the taste of blood. In 1950 there were an estimated 720 million cows in the world. Today there are nearly one and a half billion. In America there is one cow for every three people. Think of a third of a cow—that’s what’s on your plate, and you’re not getting up until you’ve finished it.
Why have we fallen in such greedy love with beef? What does steak say to us and about us? Well, it’s manly. If food came with gender appellations, steak would definitely be at the top of the bloke column. Women can eat it, they can appreciate it, but it’s like girls chugging pints of beer and then burping. It’s a cross-gender impersonation. Steak is a high-value food that doesn’t need a chef. You don’t want some twiddly-accented, jus-dribbling, foam-flicking chef mincing about with your meat. You want a guy in a checked shirt with his sleeves rolled up forking and tonging your T-bone. Steaks even come with their own butch utensils. It’s more like engineering or Lego than cooking. It’s boy stuff. The porterhouse used to be the dining choice of a gauche out-of-towner, a man who was uncomfortable with chic urban menus and didn’t know how to order—“Oh, I’ll just have the steak. Wipe its behind and bring it to the table,” they’d say, just to let the rest of us cheese-eating sophisticates know that they weren’t intimidated hicks. Restaurants would keep steak on the menu just for them because they knew there would always be a certain sort of guy who didn’t think it was an acceptable date restaurant if he couldn’t get a New York strip. Chefs hate steaks because their reputations are left in the hands of their butchers—two cuts off the same muscle can eat quite differently.
But today steak is, if not chic, then at least modern. Steak houses used to be leathery, clubbable lounges with cartoons of dead customers on the walls and faux Victorian paintings of obese cattle, staffed by ancient, permanently enraged waiters with faces as livid as well-hung sirloin and aprons that went from nipple to ankle. Now a steak restaurant is more likely to be James Bond luxurious and internationally expensive, a setting for chiseled-jawed, silver-templed seduction and couples with multiple passports. A place for men—who might fear that their testicles would pack their bags and leave if they caught them talking about terroir or heirloom tomatoes—to have a detailed and exhaustively knowledgeable discussion about dry-aging, grass-fed versus corn-fed, and the state of Wagyu-Angus crossbreeding. Steak has become the butch foodie communion, and tellingly not just for flinty-eyed, Armani-suited leaner-than-thou businessmen, but for metrosexuals who wish to beef up their cultural testosterone.
by A. A. Gill, Vanity Fair | Read more:
Photo:Dominic Episcopo; Retoucing by Stella Digita
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