by Mark Shoofs
Scientists using a powerful mathematical tool previously applied to the stock market have identified an Achilles heel in HIV that could be a prime target for AIDS vaccines or drugs.
The research adds weight to a provocative hypothesis—that an HIV vaccine should avoid a broadside attack and instead home in on a few targets. Indeed, there is a rare group of patients who naturally control HIV without medication, and these "elite controllers" most often assail the virus at precisely this vulnerable area.
Scientists have identified an Achilles' heel in HIV, the virus that causes AIDS, with a powerful mathematical method previously applied to the stock market, and think the spot could be a prime target for vaccines or drugs. Mark Schoofs explains.
Scientists using a powerful mathematical tool previously applied to the stock market have identified an Achilles heel in HIV that could be a prime target for AIDS vaccines or drugs.
The research adds weight to a provocative hypothesis—that an HIV vaccine should avoid a broadside attack and instead home in on a few targets. Indeed, there is a rare group of patients who naturally control HIV without medication, and these "elite controllers" most often assail the virus at precisely this vulnerable area. Scientists have identified an Achilles' heel in HIV, the virus that causes AIDS, with a powerful mathematical method previously applied to the stock market, and think the spot could be a prime target for vaccines or drugs. Mark Schoofs explains.
"This is a wonderful piece of science, and it helps us understand why the elite controllers keep HIV under control," said Nobel laureate David Baltimore. Bette Korber, an expert on HIV mutation at the Los Alamos National Laboratory, said the study added "an elegant analytical strategy" to HIV vaccine research.
"What would be very cool is if they could apply it to hepatitis C or other viruses that are huge pathogens—Ebola virus, Marburg virus," said Mark Yeager, chair of the physiology department at the University of Virginia School of Medicine. "The hope would be there would be predictive power in this approach." Drs. Baltimore, Korber and Yeager weren't involved in the new research.
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