Tap The Healing Power of Poop

It’s flushed down dark pipes into malodorous sewers. It is the very definition of “waste.” But it turns out that human feces may also have amazing healing properties, due to the trillions of colon microorganisms that it contains. Stool from a healthy person, recent findings show, can cure nine out of ten chronic cases of potentially deadly colitis caused by the intestinal bacterium Clostridium difficile. Moreover, healthy stool might treat a range of other disorders, from Crohn’s disease to constipation.

The procedure of transferring stool to a patient—technically called fecal microbiota transplantation—was first performed in the United States in 1958 to treat an intractable case of C. difficile colitis, a gastrointestinal condition caused when the balance of microbes in the gut—called the microbiome—is destabilized or destroyed. The goal was to banish C. difficile by overpowering it with healthy microbes so that balance could be restored. The experiment worked, and last year a review of 317 patients treated by 27 different research groups found an astounding 92 percent cure rate from this unusual therapy.

Now a group of physicians have designed the fecal treatment’s first double-blind trial, in which neither patient nor researcher knows whether a placebo or a healthy microbiome is being delivered to the ailing gut. Before that can happen, though, the FDA needs to approve the use of healthy donor stool as an “investigational new drug.” Then the National Institutes of Health must provide funding.

Colleen Kelly, a gastroenterologist in Providence, Rhode Island, who is helping design the trial, says the first patient she treated with a fecal transplant was a premed student in 2008 who was completely debilitated by six painful months of C. difficile colitis. “I tried every standard regimen of treatment. Nothing worked,” Kelly says. After the patient received a transplant of her live-in boyfriend’s stool, she was cured. “When I saw her at follow-up, she looked fantastic,” Kelly says, “smiling and completely symptom free. She told me she’d felt better the same day as the transplant. I’ve done 72 of these now, and I hear that again and again.”

Growing interest in the unconventional therapy is due in part to the fact that C. difficile colitis cases have tripled in the past decade and now afflict more than half a million people a year. “C. difficile colitis is a terrible problem, and fecal transplant results are astounding,” says Lawrence J. Brandt, emeritus chief of gastroenterology at Montefiore Medical Center in New York. He is a proponent of fecal transplant therapy as a primary treatment for C. difficile, rather than as a last resort.

by Jill Neimark, Discover |  Read more:

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