Diego Pizzagalli spent a good chunk of 10 years at Harvard doing what most professors at elite institutions do: research. Specifically, research on depression. He's fMRI'd and EEG'd a lot of gray matter, but most of his work got stuck in the lab and never evolved into any real-world application. Then he developed something that was too good to let collect dust in the hallowed halls of academia: software that he says could help treat depression.
Now with the help of the Baltimore-based startup incubator Canterbury Road Partners, Pizzagalli is set to turn his lab invention into an app. MoodTune will be a series of simple games that when played regularly, can help treat depression, Pizzagalli and his colleagues say. Turn on the app for 15 minutes a day, play through some games, and maybe it could help. Maybe, they say, in some cases, it'd be all a depressed person would need. Could something that simple actually work?
Pizzagalli started working on depression in 1999 and released some of his most important papers in 2001. The papers focused on "biomarkers," signals of response in the brain to antidepressants and psychotherapy. Take a peek inside the brain, and you can see areas light up--or fail to light up--in response to treatments. Whether an area lights up or not predicts, with considerable accuracy, whether a treatment works, he says.
So, the thinking goes, what we if we illuminate those regions another way? The brain could readjust appropriately without the need for a pill. The anterior cingulate cortex is associated with depression and also works when snap decisions need to be made, Pizzagalli says, so perhaps having someone make snap decisions would help treat depression. He developed desktop software in his lab to test it out and was happy enough with the results to delve deeper into the technology.
Software like that could make for a "bottom-up" approach to depression treatment. It could "strengthen the circuitry" of the ruminative brain. It could break the cycle of dwelling seen in so many depressives. It could be the first treatment of its kind to go on the market. But to turn the research into anything tangible took some extracurricular assistance.
by Colin Lecher, PopSci | Read more:
Photo: Center for Depression, Anxiety and Stress Research
