[ed. Also, not having a raison d'ĂȘtre - something (or someone) to give yourself to, or to live for... ]
The point at which chronic stress turns toxic is when it becomes unrelenting and traumatic, and when sufferers lack control and social support. "What we tend to mean when we talk about stress are the daily experiences of time scarcity, role uncertainty, social conflict and pressure," says Kelly McGonigal, PhD '04, a health psychologist, author and Stanford lecturer. "I've become even more convinced that the type of 'stress' that is toxic has more to do with social status, social isolation and social rejection. It's not just having a hard life that seems to be toxic, but it's some of the social poisons that can go along with stigma or poverty."