How To Make Superbabies

Working in the field of genetics is a bizarre experience. No one seems to be interested in the most interesting applications of their research.

We’ve spent the better part of the last two decades unravelling exactly how the human genome works and which specific letter changes in our DNA affect things like diabetes risk or college graduation rates. Our knowledge has advanced to the point where, if we had a safe and reliable means of modifying genes in embryos, we could literally create superbabies. Children that would live multiple decades longer than their non-engineered peers, have the raw intellectual horsepower to do Nobel prize worthy scientific research, and very rarely suffer from depression or other mental health disorders.

The scientific establishment, however, seems to not have gotten the memo. If you suggest we engineer the genes of future generations to make their lives better, they will often make some frightened noises, mention “ethical issues” without ever clarifying what they mean, or abruptly change the subject. It’s as if humanity invented electricity and decided the only interesting thing to do with it was make washing machines.

I didn’t understand just how dysfunctional things were until I attended a conference on polygenic embryo screening in late 2023. I remember sitting through three days of talks at a hotel in Boston, watching prominent tenured professors in the field of genetics take turns misrepresenting their own data and denouncing attempts to make children healthier through genetic screening. It is difficult to convey the actual level of insanity if you haven’t seen it yourself.

As a direct consequence, there is low-hanging fruit absolutely everywhere. You can literally do novel groundbreaking research on germline engineering as an internet weirdo with an obsession and sufficient time on your hands. The scientific establishment is too busy with their washing machines to think about light bulbs or computers.

This blog post is the culmination of a few months of research by myself and my cofounder into the lightbulbs and computers of genetics: how to do large scale, heritable editing of the human genome to improve everything from diabetes risk to intelligence. I will summarize the current state of our knowledge and lay out a technical roadmap examining how the remaining barriers might be overcome.

We’ll begin with the topic of the insane conference in Boston; embryo selection.

by Gene Smith, Less Wrong |  Read more:

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[ed. Response/critiques here: Statistical Challenges with Making Super IQ babies]