Showing posts with label Biology. Show all posts
Showing posts with label Biology. Show all posts

Friday, August 21, 2026

The Deep Sea

The Deep Sea
by Neal Agarwal
[ed. Fun and informative (scroll down to different depths to see the various creatures that have been recorded there). For example, I had no idea thick-billed murres could dive that deep.]

Why So Quiet?

In May 2024, when then-Congresswoman Mary Peltola introduced a Bycatch Reduction and Mitigation Act and Bottom Trawl Clarity Act, the bills drew immediate backlash.

Peltola, a Democrat, received a letter signed by 53 trawl interests and nationwide fishery stakeholders urging her to withdraw the proposed legislation saying, “These new federal mandates and timelines are utterly unworkable.”

Fast forward to 2026.

In her current campaign to unseat 12-year incumbent Republican Sen. Dan Sullivan, Peltola introduced a similar “Fighting for Alaska Fisheries” platform to no reaction from the trawl sector. Sullivan quickly followed by proposing a Bycatch Reduction Act, a revamped version of a 2022 Alaska Salmon Research Task Force bill that produced a report recommending more research. Again, no trawler reaction.

What’s the difference?

This time around, Peltola’s push is a campaign policy platform, not a proposed congressional bill. While Sullivan’s Act fits that description, the trawl sector apparently views him as its strategic shield against Peltola. If they aggressively attack his bill, they could politically weaken their strongest ally in Washington.

There are fundamental differences between the two bills.

Peltola’s approach leans toward statutory restrictions that would force the government to draw hard lines on where trawling is allowed — the goal is to stop “multi-species collapse.” It would make changes to language loopholes in the outdated Magnuson-Stevens Act, such as “minimizing bycatch to the extent practicable.” Her proposal would remove “to the extent practicable” as it is widely regarded as the phrase that allows trawlers to declare under the law that they “are doing the best they can” to reduce bycatch. It has been included in management decisions for decades as a way for the trawl sector to avoid more stringent bycatch rules. Peltola’s approach calls for restructuring the North Pacific Fishery Management Council to dilute trawler influence, and adding seats for subsistence and small-boat fishermen. It calls for investment in Alaska seafood processing innovation, fish by-product utilization and seaweed and shellfish mariculture.

Sullivan’s bill offers industrialized trawlers a heavily subsidized pathway to compliance rather than an eviction notice. It requires stricter operational rules like mandatory salmon excluders — devices built into trawl nets that can allow salmon to escape — and tougher seafloor contact accountability. It focuses heavily on using advanced data, real-time technology and gear innovations to mitigate bycatch and ecosystem impacts without adding regulatory burdens. Crucially, it includes massive federal carrots: funding for a flume tank, electronic monitoring upgrades and streamlined Exempted Fishing Permits that allow vessels to conduct experimental fishing activities that would otherwise be prohibited.

Instead of resorting to angry rebuttals, the trawl sector has outsourced its messaging to new advocacy fronts like The Truth Alaska, Sustaining Alaska’s Future and the Alaska Pollock Fishery Alliance. One originates in Texas; the others are fronted by former state directors for Republican Congressional delegates Sen. Sullivan and Rep. Nick Begich III.

This strategy lets the trawl sector counter anti-trawl sentiment without making it look like they are fighting a sitting US Senator. They reframe the debate as “supporting science and Alaska jobs,” allowing Sullivan to position himself as the reasonable middle ground.

During his tenure, Sullivan has been one of Big Trawl’s top recipients of campaign contributions. He obfuscates the fact that those cash cows all are homeported in Seattle or Oregon.

In recent social media ads, for example, he calls for reining in chum salmon bycatch by “holding foreign fleets accountable,” knowing full well that foreign fleets have been banned from Alaska waters out to 200 miles since the mid-1970s.

by Laine Welch, Alaska Beacon |  Read more:
Image: David Csepp/National Marine Fisheries Service
[ed. Politics in a nutshell (and GOP politicians) - and the natural environment continues to get screwed. I don't think Republican politicians hate the environment per se, but if the choice is between protection and unfettered development, no contest. See also: Roadless Rule to be Rescinded (affecting 45 million wild acres) here and here, and Big Bend National Park (Texas) under threat (here and here).]
***
"Donald Trump once bragged that he could shoot someone in the middle of Fifth Avenue and not lose his supporters’ faith. In the Big Bend region, the Trump administration has been figuratively shooting Texans in the face while the state’s leaders do virtually nothing. In recent weeks, bulldozers began ripping up Texas’s last, best wilderness—the one place that still honors the state’s mythology of wide-open spaces and endless frontier. Even with the federal boot heel (for now) off the neck of Big Bend National Park, it’s preparing to press down on the rest of the vast region with a mix of thirty-foot border walls, vehicle barriers, and new patrol roads. Hundreds of private landowners between El Paso and Del Rio may soon face eminent domain, their land seized by the feds for a project that few in the region think will do anything to secure a part of the border that sees vanishingly few illegal crossings.

In the face of all this, a spirited, bipartisan coalition of Big Bend enthusiasts—from crunchy river rats to MAGA border sheriffs—have been fighting back. Early in the summer, they managed to get the Trump administration to scrap plans for a thirty-foot wall in the park. This week, U.S. Customs and Border Protection commissioner Rodney Scott agreed to pause construction there while he visits the region. Governor Greg Abbott, after months of silence on the matter, has attempted to take credit for the pause."

Thursday, August 13, 2026

'Biological Datacenters' Could Make Animal Testing Obsolete

There’s a big flaw in the way that drug companies develop and test medicines today: What works in a mouse often doesn’t work in a human.

For decades, the industry has relied on animal testing. But in a laboratory south of San Francisco, a startup called Vivodyne is scaling up a different approach. Inside wardrobe-size mini labs, robots grow human tissue and run thousands of AI-designed experiments that could better predict how well a new drug will work—and whether it will be safe.

Right now, around 90% of clinical trials fail despite the fact that a drug has already successfully gone through animal testing. “You have these clinical trials where there’s hundreds of millions of dollars at stake, and decades of people’s careers just spent hoping this thing works,” says Andrei Georgescu, Vivodyne’s CEO. “And then it fails because of some ambiguity that you could not have checked.”

The company’s system, which now includes a dozen robotic labs called “hives,” can run controlled trials on more than 3 million human tissues each year. That’s twice the capacity of all the clinical trials in the U.S. combined.

The process starts with cells from humans, often taken from a blood draw. In its labs, the cells grow on “biological chips” and self-assemble into living structures with blood vessels and immune cells that reproduce some of the functions of the original organ, whether that’s a liver or a kidney. (The tissues don’t look like full-size organs, but like large biopsies, with hundreds of thousands of cells.)

The automated system can deliver drugs to the tissues, dose with cell therapies, knock out genes, and run complex tests and analysis. AI can design experiments and then use the results to continually design new experiments and improve.

“We can dose with tens and tens of thousands of therapeutic compounds to understand what they would do in that particular tissue type within a person, and we can repeat this across many types of tissue,” Georgescu says. “We can look at diseased tissue and see if it becomes healthy. We can look at healthy tissue and see if there are side effects from these drugs.” At a more fundamental level, it’s possible to begin to understand the human body in a way that wasn’t possible before, because experiments in humans have inherently been limited.

Other startups also use human tissues for testing, but Vivodyne’s platform can be up to 1,000 times larger, making it possible to capture more of the complexity of human biology. In addition, the company can run a massive number of experiments in parallel and feed the data back into AI to repeatedly design new experiments. [...]

A clinical trial might test one drug in thousands of people. Vivodyne can test thousands of different drugs across human tissues at once. And while people in a drug trial only have occasional visits to a clinic to track results, the system can continually test how human tissue responds.

by Adele Peters, Fast Company |  Read more:
Image: Vivodyne

Monday, August 10, 2026

What Would It Mean to See a New Color?

During his first year as a professor of computer science at the University of California, Berkeley, Ren Ng was hurriedly putting together a survey course on computer graphics. In the syllabus he had inherited, a full week had been devoted to the subject of color. Ng thought that was a bit much. “I’m, like, Come on. It’s R.G.B.,” he said, referring to the red, green, and blue subpixels that constitute anything you see on a screen—your cluttered desktop, a Sahara-desert screen saver, the stream of the Netherlands-Japan World Cup game. Ng started gathering slides that would cover the wavelengths of light, the biology of the human eye—the basics—“Blah, blah, blah,” he said. A colleague shared a slide that he thought might be useful. It included a minutely detailed photograph of a patch of retina, seen through a microscope, which was attributed to Austin Roorda, a professor of vision science and optometry just across campus. Roorda’s lab had helped develop technology that could map the layout of individual cone cells—those primarily responsible for perceiving color—and that, furthermore, could target a single cone cell with light. Eyes are constantly moving; cone cells are extremely small; how color is translated from the millions of cone cells to the mind remains pretty mysterious; this was awesome work. Roorda’s lab was using the new technology to explore eye disease and the mechanics of how we see. Ng had his own notion, though: he wondered if it could be used to see a color that had never been seen before.

To understand what Ng had in mind requires knowing a bit of the blah, blah, blah of color vision. We humans experience three primary colors not because the world is fundamentally composed of three colors but because our retinas typically have three kinds of color-perceiving cone cells. L cone cells respond to the relatively longer wavelengths of visible light, M cone cells to the medium wavelengths, and S cone cells to the shorter ones. In effect, this means that L cells respond most strongly to red light, M to green, and S to blue. But when you look at your hand—or a blade of grass, or a clear blue sky, or a fire truck—it is always some mixture of L, M, and S cone cells that are being stimulated.

Ng’s idea was to use the Roorda lab’s technology to stimulate an array of cone cells in a manner that would never occur naturally. Ng said, “I e-mailed him, basically, What would happen if you stimulated only the M cells? Would that be like the greenest green, or what?” Roorda did not reply. This was 2016. Ng taught his computer-graphics course, pursued other research, and mostly forgot about his query. A year later, when he taught the course a second time, his curiosity returned, so he reached out to Roorda again. No response. When Ng was teaching the course for a third time, in 2018, he realized that he really was very curious about this question. He composed a lengthy note to Roorda, organized like a research proposal, titled “The Grass Is Greenest in Oz Vision.” In it, Ng imagined a future where people wore “Oz Vision eyeglass displays,” which would be based on the retinal cone-cell mapping and laser stimulation that Roorda’s lab was already doing. The Oz glasses would activate any pattern of retinal cone cells one chose. Ng’s hypothesis was that, if retinal cells were stimulated in ways that don’t occur naturally, “the set of perceivable colors” would be “significantly larger than the natural gamut of the human eye.” He imagined people discussing “the indescribable green of the grass in Oz,” then concluded that, although the Oz display “is science fiction,” his note was “a real proposal for joint research.” Roorda finally replied, proposing coffee. “I get a lot of e-mails suggesting what I should research,” Roorda told me, of the time it took him to respond.

In the children’s novel “The Midnight Fox,” by Betsy Byars, the main character daydreams about digging in his back yard and coming across a “brand-new color.” A friend of mine remembers being captivated by this scene, and trying to picture the color. “I felt like I could conceive of it, but I couldn’t see it,” she said. The eighteenth-century Scottish philosopher David Hume considered at length whether a person who had seen every shade of blue except for one would be able to picture that one un-experienced shade; he concluded that the answer was yes. In my youth, I spent an afternoon wondering if I would have been able to imagine the fluorescent yellow of highlighter markers if I’d never seen it.

When I first read about Ng and Roorda’s work, I tried to visualize what it would mean for there to be a new color. Where would it go in a color wheel? If you think of color as a property of a specific wavelength of light—which is how I thought of it—then you run into the impossibility of there being a “new” visible wavelength. As humans, we can see wavelengths from roughly 380 nanometres (which looks violet to us) to about 750 nm. (which looks red). Wavelengths shorter than 380 nm., which we’d call ultraviolet, are invisible to us (but not to bees or hummingbirds), as are wavelengths longer than 750 nm., which we refer to as infrared (and which snakes and salmon can perceive). The “greenest green” that Ng had in mind was neither ultraviolet nor infrared. It was not a new wavelength at all. If I wanted to picture this green, or at least try to, I would first have to understand that even the old familiar colors are much more complex than a particular wavelength of light.

by Rivka Galchen, New Yorker | Read more:
Image: Zach Lieberman

Thursday, August 6, 2026

Sheep that Bleat

My dog Toby and I were just back from our early morning walk and I was in the living room when I heard a single bleat of a sheep. It was 8:30. The sheep bleated again.

How to describe the sound? Demanding, worried, and hesitant. Half, “Well, what?” and half, “Oh dear, oh help!” Half low moan, half high and wavering supplication. It’s a sound, like birdsong, that I’d have to replay endlessly to describe even half-right. And yet I recognized it immediately as different from the bleating of the small herd my neighbor’s nephew Jesús keeps in the fields across the lane from my house. This mournful bleat proclaimed, I am alone.

I looked out the window and saw the animal, emerging from the shadows where the lane dead-ended at the gated entrance to a field. It hesitated, then, almost deerlike, it advanced. What was it doing here, and where had it come from? Behind it I could see the fence at the entrance. It appeared intact. Beyond were the green fields where the sheep grazed among the partially built houses of an abandoned project on the ridge above the river. The bank owns the land now, but my neighbor’s family has the use of the fields. No other sheep were in view.

My son had heard the sheep, too, and we both stepped out into the lane. The sheep retreated into the corner against the fence. We didn’t have the nephew’s number, so we called my neighbor instead. He was in Holland, visiting his son for a few days, but he assured us he’d call his nephew right away. For good measure, he also gave us the number.

My son and I kept an eye on the sheep. I knew that my neighbor’s sister and nephew lived five minutes away. I expected them any moment. The sheep made a couple of tentative starts into the lane but retreated each time to its corner. The third time, instead of turning back when it came up against us in the lane, it stood its ground. Then it took courage, gathered itself, and made a mad dash around us—to the freedom of the open lane, nothing to stop it or impede its progress. It looked like a young male—I could see its testicles. I followed and saw it turn off the lane onto the grassy slope behind the sports center. If it continued in that direction, it would hit city streets. I moved back, hoping it would not press on. The grass on the slope was very green. Maybe the sheep would linger to nibble.

Back at the house, I wondered what was taking the owner so long. I went inside, but a few minutes later, from the corner of my eye, I saw a sheep in the lane, just like the earlier one, drumming up its courage to get past my son, still outside. Wait! I shook my head. It felt like déjà vu.

“Same one?” I asked, stepping back outside, and my son said yes, same one—back in its dead end, only to try to escape again. And still no nephew. My son sent a WhatsApp message.

The sheep made a last attempt. My son and I, prepared this time, jumped in front of it, waving our arms. At the last moment, the sheep veered, turned, and charged back to its corner. It made a funny little leap into the air, twice, to come down on all four feet in a show of petulance. Then it lay down on a patch of grass by the gate. Shortly afterward, a car pulled up.

Instead of the story ending, however, it took a turn. Rather than the nephew, it was his mother, with his girlfriend driving. The women explained that they got a call from my neighbor, explaining that the nephew hadn’t picked up. The mother and girlfriend couldn’t get in touch with him, either—the man was at work. So they’d come.

I pointed out the sheep, lying quietly in the shade of the wall. The sister wore a worried expression. The girlfriend seemed amused. How do we catch it, I asked? Oh, we won’t, the sister said. Another nephew in the family, cousin to Jesús, was coming. He would catch it.

So while we waited for the cousin, we watched the sheep. It was on its feet again. Was it favoring the front left leg, injured perhaps while wriggling free through a fence? Would it put up a fight? While we talked, a call came: Jesús, finally alerted by my son’s message. His mother passed the phone to the girlfriend. The cousin appeared, climbed out of his car, engine running and door wide open. He was looking past us as he advanced toward the sheep, backed up against the gate. Almost immediately, even before he’d had time to size up the situation, he turned to us. “That’s not Jesús’s,” he declared. The girlfriend passed the phone to the cousin, and in a minute he passed it back to her. She passed the phone to Jesús’s mother, as if rewinding a skein that had come unwound. A few words to Jesús, and the mother hung up.

“Well, whose sheep could it be, then?” I wondered aloud.

Nobody knew. Call the police, the cousin said, and left. The two women got in their car to drive off, too. As they turned the car around, I stepped up to the window. “Did you call?” I asked.

“No, no—we don’t have the number.” And they too drove off. I stared after them. Well, why wouldn’t they leave? The sheep wasn’t theirs.

It wasn’t mine, either, though.

To me, it looked like a sheep had been dropped among us, and we should all make a contribution to getting it where it belonged. My 45 minutes counted as my effort. What was theirs?

To them, the situation might look different—as if I’d started it all by worrying about a sheep when it wasn’t my business to worry about it, disrupting the morning of any number of people by involving them, too. And now I was trying to hand off the Old Maid card. They weren’t taking it.

by Clelland Coe, American Scholar |  Read more:
Image: John Fowler/Flickr

Sunday, August 2, 2026

Salmon Sushi: Not a Japanese Tradition

Somewhere in Tokyo in the mid-1980s, a Norwegian marketing strategist stood in front of a room of Japanese seafood executives, served them raw salmon, and watched the room politely fall apart. The colour was wrong, they told him. Its smell, they said, had a river-like quality. Someone objected to the shape of the fish’s head.

I think about that meeting every time I sit at a conveyor belt and watch the orange slabs go past. Salmon nigiri has the settled look of something that was always there, parked next to the tuna and looking as venerable as a prawn tempura. It has been on Japanese menus for about thirty years.

What Japan actually ate before

Japanese cooks have used salmon for centuries. They grilled it, salted it, flaked it into rice balls and packed it into lunchboxes. Nippon.com describes grilled salmon and salmon flakes as fixtures of home cooking, with a hard line drawn between that cooked fare and anything sliced raw. The domestic workhorse was chum salmon: lean, firm, nobody’s idea of sashimi.

So the fish was there. The appetite for raw fish was very obviously there. Those two facts never met.

The parasite question, answered properly

There was a real reason for the line, and fussiness was not it.

Wild Pacific salmon carry Anisakis simplex, a nematode larva that causes a thoroughly miserable illness called anisakiasis if you swallow it alive. Heat kills it. Deep freezing kills it. Slicing the fish fresh and eating it does not, which is why generations of Japanese cooks treated raw salmon as a hazard to be cooked out.

Farmed Atlantic salmon raised on heat-treated pellets is a different animal. The Norwegian Food Safety Authority exempts farmed salmon and rainbow trout from the freezing rule that otherwise applies to fish destined to be eaten raw, on the grounds that the fish eat nothing but dry feed containing no viable parasites and barely graze on wild organisms in the pen. That exemption tracks a 2010 European Food Safety Authority opinion and its 2024 re-evaluation.

A survey published in the Italian Journal of Food Safety put numbers on it: 270 slices of smoked farmed Atlantic salmon examined, zero anisakids found, against ten positives out of thirteen slices of wild sockeye. One paper on one processed product, not a settled literature, but it points the same way the regulators do.

Norway had too much fish

Norway started farming salmon commercially in the 1970s, then watched its own population drift towards chicken and red meat.

Freezers filled up.

The Norwegian Seafood Council, which has every commercial reason to tell this story well, dates the campaign to 1985, when a delegation led by former fisheries minister Thor Listau flew to Tokyo. Their figures: two tonnes of Norwegian salmon went to Japan in 1980, and twenty years later the annual number was above 45,000 tonnes.

Underneath all of it sat one piece of arithmetic. Fish sold for the grill competes on price with every other cheap protein, while fish accepted for sashimi could fetch up to ten times more, as Bjørn Eirik Olsen, who ran market research for the project, later told The Japan Times.

A name change, then a decade of nothing

“We couldn’t just say that our fish doesn’t have parasites,” Olsen said in that interview. Walking into a foreign industry and announcing that its national fish is wormy tends to close doors rather than open them.

So he went after the word instead. The Japanese for salmon is sake, and sake carried every association he was trying to escape: grilled, salted, cheap, the thing in the lunchbox. Olsen borrowed the English word and pushed the katakana sāmon, the term still stamped on essentially every sushi menu in the country. Same animal, different shelf.

Then came the advertising, all clean fjords and clear arctic water, and it achieved almost nothing for years. Olsen told NPR that pressure from home to abandon the sushi idea and dump the stock into the grill market was relentless.

The deal that broke it open

In 1992, Olsen offered the frozen food giant Nichirei 5,000 tonnes of salmon at close to giveaway prices, with one condition written into it: the fish could only be sold as sushi. Nichirei said yes.

That was the crack in the wall. Through the 1990s, Iron Chef and celebrity chefs including Yutaka Ishinabe put Norwegian salmon onto national television, and appetite did the rest. Olsen has said he knew the campaign had landed when he started noticing plastic salmon nigiri in restaurant window displays.

Where salmon sits now

Salmon has topped Japan’s biggest conveyor-belt sushi survey for fifteen consecutive years. In the 2026 round, run by Umios (the company known as Maruha Nichiro until March), 47.7 per cent of respondents named it as the topping they eat most often, more than eleven points clear of lean tuna in second place. The split runs along age lines: older diners tend to open with lean white fish and work up to tuna, while younger ones go straight for the orange.

by Daniel Moran, Space Daily |  Read more:
Image: uncredited
[ed. Not many people know this but there are actually six species of Pacific salmon (not five), including the cherry salmon (Oncorhynchus masou) in Japan.]

Saturday, August 1, 2026

Astronauts Returning From Six-Month Missions Describe a Persistent 'Observer' Sensation

Astronauts coming home from long stays on the International Space Station have, for years, described a strange perceptual aftertaste: a sense of watching their own lives from a half-step outside the frame. They sit at dinner with family and feel like a guest. They drive on a familiar street and feel like they’re piloting it. The room is loud and they are in it, but a part of them is hovering near the ceiling, taking notes.

It is not a clinical diagnosis. It does not appear in a DSM. But flight surgeons and crew psychologists who debrief astronauts after six-month rotations describe it often enough that it has become a recognizable readjustment pattern — an observer sensation that lingers for weeks, sometimes months, after splashdown.

What returning crews actually describe

The descriptions are remarkably consistent across agencies. Crew members talk about feeling slightly delayed in conversations. They report a doubled awareness — being present while also watching themselves be present. Some say it feels like the first week of a new job that never quite ends. Others compare it to jet lag of the self.

NASA’s own post-flight reflections from station crews describe the sensation in plainer language: home feels staged. Smells are too sharp. Gravity feels theatrical. The brain, which spent half a year recalibrating for a world without down, treats the familiar as something to be studied rather than inhabited.

Returning astronauts describe walking into their own homes and feeling like they are visiting them. Some talk about being unable to put a glass down without watching their hands do it. The pattern shows up in oral histories, in memoirs, in flight surgeon notes. It is one of the quieter costs of long-duration spaceflight.

by Space Daily, Editorial Team |  Read more:
Image: T Leish on Pexels

Tuesday, July 21, 2026

How Leprosy Was Used as a Weapon Against Hawaii’s Indigenous Population

Father Damien was a dirty man. Everyone agreed on that. Dirt would accumulate under his fingernails; he rarely washed his hands. His clothes—his habitual cassock and wide-brimmed hat—were worn for days on end; he saw no reason to clean his hut in Kalawao, the leprosy colony on the Hawaiian island of Molokai. His detractors claimed he lacked elegance too: burly with a “piggish” head, they complained, he squinted from behind a pair of wonky wire-framed circular spectacles. He was eager to learn Hawaiian, it was noted sniffily, but otherwise he had little enthusiasm for languages. His Latin came only by official requirement, his English was sparse; a native Flemish speaker, even his French was stilted. The prose of his letters lacked refinement whatever their language: “coarse…headstrong and bigoted” was one particularly vitriolic posthumous assessment.


None of this worried Damien. Hawaiian did him fine. From that messy home, built in sight of Kalawao’s cemetery, Damien wrote to his brother Auguste, also a priest, to say that Molokai was exactly where he wanted to be.
"We eat what Providence sends us. The calabash of poi is always full; there is also meat; water in quantity, coffee and bread sometimes, wine or beer never. As I have had to work all week and cook on Sunday, you will excuse me if my hands are not as clean as yours, which do nothing, I suppose, but turn the pages of books. Sometimes the plates are not well washed either. But what matter. Hunger and habit make us eat just the same. For dessert, we smoke a pipe. That finished, quickly back on the horse."
In the saddle, Damien would cross Molokai’s mountains; his parish over two thousand square kilometers, he rode down the island’s valleys beyond Kalawao itself, across water and through fields to find the most remote of his parishioners. Today it is a national park, wild garlic growing in fragrant profusion, its white flowers poking up between ferns, yellow hibiscus and amid the ki-tree, the roots of which were used to brew a potent beer. Across this paradise the finch-like honeycreeper flits, feeding off the red spindly flowers of the evergreen ‘ōhi‘a lehua tree. Damien would haul building material and basic medical supplies with him, eager to provide practical as much as spiritual comfort (though he never left without an ad hoc altar of four sticks and a plank). Sometimes he had to abandon the horse and mules to scale by hand and foot the sheer cliff faces which routinely stood between him and his flock. For Damien dirtiness brought him closer to godliness, the grime evidence of his graft.

For his colonial masters, those disdainful of his personal habits, the priest’s life was alien at best and an affront to Western order at worst; religion was supposed to be a cleansing antidote to indigenous habits, a washing-away of the idolatry and idleness they projected onto the population, be they sick or healthy. Yet here was Damien, adopting their ways, it would seem, along with their language. His body and the leprous bodies of his parishioners were dangerously entangled even before he himself succumbed to the disease. This was 1872, and the pious (and patronizing) commentators of the time muttered that Damien’s unvarnished personality was due to his simple farm upbringing in rural Belgium. “It is absolutely beyond doubt that he contracted the disease through his careless ministrations and uncleanly personal habits,” a representative of the Hawaiian Board of Health tutted, though not without something approaching admiration, noting the priest “would have leper boys at work in his kitchen so that he could give more time to his ministrations for others, being busy from peep of day until long after dark.” Dirty of body, dirty of mind, would be the eventual assumption: sexual proclivity was whispered. Damien’s brother, reading Latin scripture in a clean cassock 12,000 kilometers away, faced no such danger and no such accusations of moral lapse.

Damien was never supposed to achieve the fame he did, a symbol of global imperial paranoia and catalyst of religious fetish: a bronze statue, in which he wears his wide-brimmed hat, stick in hand, now represents the state of Hawaii in the US Capitol building’s Hall of Columns. He was never supposed to be the subject of culture wars in his lifetime and long after: in 2020, Congresswoman Alexandria Ocasio-Cortez decried the choice of a white man as Washington’s symbol of the Polynesian fiftieth state. Damien was supposed to stay working in his parents’ fields in Tremelo, a dull village in a duller part of Belgium. The fact that celebrity landed upon him, plucking him from the obscurity of his mission to represent the burgeoning discourse on the disease, says more about the world that orbited him than his actions on the island or his own political nous. There were plenty of other missionaries, in plenty of other colonies, with plenty of other health issues, spreading religion and the soft arm of imperialism. Leprosy, however, had become totemic of a moral depravity or sexual freedom that Europeans had long imagined pervaded the South Seas. The leprous, lascivious body was a perversion that Western proselytizing could fix.
***
For indigenous Hawaiians, leprosy arrived as Damien did, an unwanted visitor from across the sea. The disease may have stowed away as early as Captain Cook’s colonial voyage, but it only became regarded as a public health issue eighty years later. “The commander manifested a laudable humanity, in endeavouring to shield the population from the evil effects which so inevitably result from connection between foreign seamen and the native females,” wrote one sympathetic European account of Cook’s trip. The evil effects weren’t just moral turpitude, but disease too. “But his efforts were in vain. If the discipline of his own crew could have been strictly enforced, the eagerness of the women was not to be repressed.” Historically, this genesis, regardless of whether the women were actually consenting, inextricably linked sickness with sex in the minds of Hawaiian and colonialist alike, with the former’s lack of conformity to Western and Christian mores taking the brunt of the responsibility in the minds of the latter.

The haole—the white incomers—dodged blame from among Hawaiians for leprosy too. As cases multiplied, the disease became known as ma‘i pake, the “Chinese sickness,” named after the thousands of Chinese laborers who arrived on the islands at the invitation of American traders endeavoring to create an export market in sandalwood (a precursor to the sugar industry that would dominate the economy in years to come). “There seems but one way to prevent the whole of Oceania from becoming leprous, and that is the exclusion or the rigid control of all Chinese coolies,” a Scottish physician warned. Wherever it came from, contact was devastating for the indigenous Hawaiian population, which plummeted from the healthy 683,000 people Cook first encountered to just under 40,000 Polynesian islanders left after a century of colonial enterprise and disease.

by Oliver Basciano, Literary Hub |  Read more:
Image: Kalaupapa, Molokai

Tuesday, July 14, 2026

Paradise Revisited

The Galápagos Islands owe their place on rich travelers’ bucket lists to the vision of them as an unfallen Eden, touted as “the laboratory of evolution” that inspired Charles Darwin to write On the Origin of Species. When he visited, humans’ presence here was limited to whalers, buccaneers, and political prisoners. Today, more than 300,000 people visit the archipelago each year. Every tourist desperate to see an untouched paradise is part of a constant influx that risks despoiling the very thing they came to see.

On his arrival, in 1835, Darwin marveled at the lack of fear shown by all the animals, thanks to their limited exposure to humans. “Met an immense Turpin: took little notice of me,” he wrote in his field notebook about encountering a tortoise on September 21. Perhaps the poor turpin should have been more wary: By October 12, Darwin was recording that he had been “eating Tortoise meat / By the way delicious in Soup.” Soon he was trying to ride them. “I frequently got on their backs,” he wrote in the published version of his diaries, “and then giving a few raps on the hinder part of their shells, they would rise up and walk away;—but I found it very difficult to keep my balance.”

On these parched islands, the tortoises were prized for their ability to slurp moisture from prickly pear cacti, and to drink enough at the rare springs to sustain them for months on end. Thirst-racked sailors would catch and kill them purely for the contents of their bladders. “In one I saw killed, the fluid was quite limpid, and had only a very slightly bitter taste,” wrote Darwin, having sportingly chugged some tortoise urine for science.

Today, none of this is allowed. El Chato Ranch, which I visited in the pouring rain, permits selfies with its resident tortoises but absolutely no touching, eating, or disemboweling. Most of the Galápagos have been designated by Ecuador as a national park, with a $200 entrance fee—­up from $100 just two years ago—­and a strict injunction to stay six feet away from the animals. The archipelago is also home to the flightless cormorant, whose former wings are now stumpy nubs; a species of batfish that looks like it is wearing bright-red lipstick; and the marine iguana, which ejects excess salt from its body by sneezing. (Catch a big group at the right moment and they can go off like the cannons in the 1812 Overture.) These animals all exist in the Galápagos and nowhere else.

The usual story of Darwin’s visit is that he cataloged the small differences that had emerged in animals across the islands—­discrepancies in the beaks of the finches being a prime example—­as each species responded to the unique conditions. In a flash of insight, he understood the mechanism of evolution: survival of the fittest. The truth is more complicated, and more interesting. His ship, the H.M.S. Beagle, spent only five weeks here, and Darwin landed on just four of the 13 major islands. At first, he did not recognize the importance of the variation among the islands, and did not label many of his bird specimens with their precise origins. The greatest study of what we now call “Darwin’s finches” was done by a British couple, Peter and Rosemary Grant, who visited the same uninhabited island, Daphne Major, every year from 1973 to 2013.

Darwin also didn’t notice the numerous subspecies of giant tortoise until the vice governor called attention to their variety and declared “that he could with certainty tell from which island any one was brought,” the naturalist wrote in his field notebook. Tortoises on Hood and Charles Islands, for instance, had evolved shells that were curved upward at the front like a saddle, allowing their necks to reach higher vegetation. Oh, and Darwin didn’t even coin the phrase survival of the fittest. That came from one of the early reviewers of Origin, Herbert Spencer. Darwin liked it so much that he incorporated it into later editions.

The mythology of blinding-­inspiration-in-paradise is so appealing that it has outcompeted the truth. The actual story—­the one that drove me here—­is that Darwin was above all an empiricist. He took nothing on trust. He wanted to see things for himself, measure them, catalog them, and perhaps even eat them, and he was willing to endure any combination of boredom, nausea, and danger to do so. He was an omnivore, as interested in geology as biology when he toured South America, and his most famous theory drew on economics as well. He had an ego, definitely, but he was also open-minded and curious; he wanted to understand nature, not just plunder it like so many colonial explorers. (In later life, he supported animal charities and called for vivisection to be regulated.) He was willing to push back against editors, too, such as the one who suggested that he should reframe Origin to focus only on pigeons, because “everybody is interested in pigeons.”

All of that should make him any writer’s hero.

The British first named the individual islands in the 1600s—Charles Island after King Charles II, James Island (where Darwin spent most of his time) after the King’s brother, and so on—­although most guidebooks now use the official Spanish names. Today Ecuador treats the Galápagos as precious jewels for both noble and commercial reasons. To enter, you need to complete a bio­security declaration, promising not to introduce any plants or animals that could rampage through this delicate ecosystem. There are no international flights into the archipelago. For me, the two-hour flight to the territory’s main airport, on Baltra Island, came at the end of a tiring slog from London to Miami, and then on to Quito, the high-altitude Ecuadoran capital, where the thin air gave me a headache the instant I stepped off the plane.

I consoled myself on the long journey by reading accounts of Darwin’s five years on the Beagle, which were marked by seasickness so intense that he traveled overland by horse whenever he could, catching up with the ship farther along its journey. “I hate every wave of the ocean, with a fervor, which you, who have only seen the green waters of the shore, can never understand,” he wrote to his cousin William. His captain, Robert FitzRoy, recorded that Darwin was “a martyr to confinement and sea-sickness when under way.”

One of the great mysteries of Darwin’s life is how he made such a success of his five years at sea, which came between a direction­less youth and an adulthood blighted by anxiety and illness. When he left England, at age 22, he was a dilettante who had washed out of medical school and was wavering about becoming a parson. His main interaction with birds and mammals was shooting them. He returned from his sea voyage a more serious and ambitious man, but one plagued for the rest of his life by vomiting, palpitations, “extreme spasmodic daily & nightly flatulence,” and vague, shifting symptoms of mental distress. He installed a lavatory behind a screen in his study at Down House, in Kent, so that he could void himself from either end as necessary and quickly return to work.

During his half decade on the Beagle, though, Darwin worked steadily, sending crates of specimens home on passing ships, and he endured the loneliness and ennui of the voyage with remarkable fortitude. Time at sea was notoriously hard on sailors’ ­mental health; the Beagle’s previous captain, Pringle Stokes, had killed himself during the bleak southern winter. (The weather was so dreary, he wrote in June 1828, that “the soul of man dies in him.” A month later, he put a gun to his head in his cabin.) FitzRoy took over as captain soon after, and decided that on his second Beagle voyage, he would take a gentleman companion to jolly him along. He and Darwin ate meals together and talked about current affairs, tiptoeing around their different political backgrounds (FitzRoy was a Tory; Darwin was from a Whig family) and intensity of religious belief (FitzRoy was a creationist; Darwin, even then, was a doubter). He gave Darwin the affectionate nickname Philos, for “natural philosopher.”

In addition to seasickness, Darwin had to brave an equatorial climate far removed from the English Midlands, where he (and I) grew up. The midday sun is directly overhead, and on the youngest islands, which have little soil and therefore little vegetation, there is no shade to hide in. “Nothing could be less inviting than the first appearance,” he wrote on landing at Chatham Island (now San Cristóbal, the seat of government). “The dry and parched surface, being heated by the noonday sun, gave to the air a close and sultry feeling, like that from a stove: we fancied even that the bushes smelt unpleasantly.” And this was in September, the cooler of the two seasons! I had come during the first half of the year, the hotter rainy season, when the seas are warm, the air temperature is about 80 degrees Fahren­heit, and the humidity wilts you like spinach.

On the first full day, crossing a scorching beach on the way back from seeing the marine iguanas at Tortuga Bay, I began to suffer from some sort of humidity-induced delirium, despite unfurling a legionnaire’s hat over my neck and shoulders. I distinctly remember thinking at one point that I had to “lock in,” the kind of extreme-sports jargon that my fully operational mind would disdain. After I had arrived safely at the hotel and rehydrated aggressively, I was amazed once again that Britons managed to explore and conquer so much of the globe, despite our manifest maladaptation to anything other than mild drizzle. That we did so before the advent of wicking fabrics, bug spray, and SPF 50 is even more implausible; I felt as ill-­prepared for the climate as Captain Scott did when he relied on ponies rather than sled dogs in Antarctica, or the equally doomed Burke and Wills expedition, which took 20 tons of equipment, including a Chinese gong, into the Australian outback.

Unfortunately, what drove some of those early explorers was an unfounded (and occasionally fatal) sense of racial superiority: Europeans knew best. On FitzRoy’s previous Beagle voyage, in 1830, a whisper of this attitude crept into the ship’s scientific mission to map the South American coastline. At the southernmost tip of the continent, Tierra del Fuego, FitzRoy effectively kidnapped four Indigenous people as revenge for the theft of one of his boats. He gave them allegedly English names—­York Minster, Jemmy Button, Fuegia Basket, and Boat Memory—and took them back to England. (The birth names of the first three were Elleparu, Orundellico, and Yokcushlu; Boat Memory’s name has been lost.) The idea was that they would be “civilized” and returned, accompanied by a missionary, to convert their benighted fellow Fuegians to Christianity.

In fact, the missionary bailed after experiencing a few days of harsh Fuegian life, and the Fuegians quickly reverted to their ancestral ways. “Captain Fitz Roy could never ascertain that the Fuegians have any distinct belief in a future life,” Darwin observed in his diaries. To the average Victorian gentleman, this was proof enough that they were “savages.” I wonder, though, if the assertion gnawed at Darwin, given that his research was already drawing him away from religious faith. “Science has nothing to do with Christ; except in so far as the habit of scientific research makes a man cautious in admitting evidence,” he would write to a friend toward the end of his life, adding: “As for a future life, every man must judge for himself between conflicting vague probabilities.” [...]

Today, Darwin is known as the great heretic, the man whose work shocked the Victorian establishment and undermined the Church. But the exact heresy he committed is not well understood. He was not the first person to suggest that species evolve—­in fact, his own grandfather Erasmus had suggested that all warm-blooded animals might have arisen from “one living filament” in his 1794 book, Zoonomia. Darwin was also not the first person to notice that the boundaries between species were more fluid than the Swedish taxonomist Carl Linnaeus had acknowledged. (The Comte de Buffon, a French biologist, had done so at the time.) And he was far from the first Victorian intellectual to question the spurious biblical chronology suggesting that the Earth was created on Sunday, October 23, 4004 B.C.E. He didn’t even come up with the idea of selection pressures, per se—­he got that from an economist, Thomas Malthus, who suggested that human populations tended to outgrow their available food sources and suffer famines as a result.

No, what offended some of Darwin’s early readers was that his vision of the universe counted humans as just another animal, rather than God’s special creation. Accepting evolution meant having “an ape for a grandfather,” as one observer put it. From the start, Darwin understood the political and religious implications of this, and he knew that advancing the notion publicly would make him a controversial figure. His own wife, Emma, was a devout Christian; some of his friends and colleagues were too.

After returning from the Galápagos, he spent more than two decades noodling in his “transmutation notebooks” without having the courage to expose his ideas, and his evidence, to universal scrutiny. In 1844, he wrote to his friend Joseph Hooker: “At last gleams of light have come, & I am almost convinced (quite contrary to opinion I started with) that species are not (it is like confessing a murder) immutable.” It is like confessing a murder. Another decade-plus passed before he was driven into print by the unwelcome discovery that another scientist, Alfred Russel Wallace, had independently arrived at the same conclusion.

The publication of Origin, in 1859, gave everyone in Victorian polite society the opportunity to have an argument that had been brewing for many years. Soon after its release, Darwin’s critics and defenders clashed in a public debate that pitted the fierce Darwinian Thomas Henry Huxley against the bishop of Oxford and the former Captain FitzRoy, who preferred to believe that the fossils they had seen together in Patagonia had been deposited there by the biblical flood. (Darwin was too anxious and flatulent to attend himself.)

by Helen Lewis, The Atlantic |  Read more:
Image: Will Matsuda for The Atlantic

Wednesday, July 8, 2026

Air Conditioners to Anchovies

China keeps the U.S. and Japan Cool. And most other places. The Chinese make more than 80% of the world’s air-conditioners. And they could… stop. 

The world’s biggest fan clubs for air-conditioning are the United States, and two Asian allies/ vassals, Japan and South Korea. In these three places, 88% to 91% of homes have such devices (IEA estimates). 

The demand for Chinese air-cons is rising world-wide, as heatwaves proliferate. Viral videos this week show customers fighting over the devices at shops in Europe. 

Is there any risk of China halting exports, in the way the US might do? Thankfully not, at the moment, analysts say. China keeps the industry entirely politics-free: We build, you buy, at a price that benefits both sides. 

The 'Assembled In...' Trick

The world has 2.4 billion air conditioners, according to estimates from the International Energy Agency. But few people around the planet are aware that their aircons come from China, because of branding techniques.

by Nury Vittachi, X | Read more:
***
One of the world’s current hottest commodities is in the midst of a huge disruption. It may sound like I’m talking about oil and the blockade of the Strait of Hormuz, but this is even more severe. The supply shock is far greater — and so is the price response: Global production has plunged as much as 40% from a year ago; prices are up 80% over the same period to an all-time high. The commodity in question? The humble anchovy.

The tiny fish may sound utterly mundane, but its importance to the global economy is far larger than just foodies’ craving for the umami taste. The anchovy sits at the bottom of a crucial supply chain that sustains the $500-billion-a-year global aquaculture industry. Anchovies are the main ingredient in fishmeal, and without enough of it, global production of salmon, seabass, shrimp, oysters and other seafood will suffer, pushing up supermarket prices. Soon, the shortage could catch the attention of Wall Street and central banks. 

Peru is the Saudi Arabia of anchovies — its annual catch, after drying and milling, accounts for about 20% of the world’s supply of fishmeal. Add the catches of neighboring Ecuador and Chile and you have nearly a third of global output. And therein lies the problem.

Because the South American anchoveta species has a relatively short lifecycle, its population can rise and fall substantially every year depending on environmental variables. The key one is El Niño, the weather event that regularly warms the waters of the Pacific Ocean near the Equator, reducing the stock of nutrients and, therefore, of fish. [...]

In mid-May, Peru imposed a 15-day ban on anchovy fishing; the moratorium was later extended until June 10. Then, the government in Lima shocked the fishing business with an indefinite ban. The South American anchoveta is the world’s largest single-species fishery. The ban has triggered a dramatic drop in global fishmeal production, which industry executives estimate to be down 30% to 40% from a year ago.

With demand from the aquaculture industry still strong, the cost of fishmeal in the wholesale market has nearly doubled over the last year to an all-time high of $2,990 per metric ton in late June. Further increases are likely. As feed prices rise, aquaculture companies will respond by trimming output, and the cost of cultivated fish and seafood will climb over the next year. [...]

Once upon a time, this would have been a first world problem. Not anymore. Back in 1997-1998, the last time the world faced a very strong El Nino and, as a result, a fishmeal shortage, the aquaculture business accounted for less than a quarter of the world’s fish supply. Since then, the size of the industry has exploded, and today the world consumes more than half of its fish and seafood from farms, requiring a huge fishmeal supply. At the same time, fish consumption per capita has also jumped, reaching 21.3 kilograms per year in 2024, up from 14.3 kilograms on average in the 1990s, according to data from the Food and Agriculture Organization of the United Nations.

If the industry’s fears are confirmed, salmon prices are likely to rise to an all-time high by 2027. Salmon is the highest-value farmed fish worldwide. The rise of the aquaculture industry transformed it from a luxury into an everyday supermarket purchase, with its price dropping from about $8 per kilogram in the early 1980s to an all-time low of $2.50 per kilogram in the early 2000s. Since then, it’s risen above $10 per kilogram. Industry executives are tight lipped about how much prices could increase, but 20% to 25% seems like a reasonable expectation.

by Javier Blas, Bloomberg |  Read more:
Image: REDA/Universal Images Group Editorial
[ed. Globalization and supply chain logistics.]

Attempted Coop

The Vances added a chicken coop to the vice president’s residence. We had questions. (Washington Post/Seattle Times).
Images: Marvin Joseph/The Washington Post
[ed. That coop looks better than some Seattle apartments. My son and family raise chickens (and ducks). They're pretty cool. The ducks are way cooler, though.]

Wednesday, June 24, 2026

Home Invasions

At four in the morning I heard a scratching that sounded like someone was trying to break into our new home. J. and I were not yet fluent in the house’s natural yawning and moaning—the way it sighed when stretching its pilings and beams, or grunted against a pummeling Florida gale, or shuddered when thunder clapped—and I often startled at sounds, trying to discern which ones required attention. And I’d recently been diagnosed with partial hearing loss in my right ear, which meant I couldn’t make out certain sounds but also imagined noises that weren’t there.

In the predawn dark it was hard to tell if my tenuous hearing was playing tricks on me. Then I felt a paw press my calf. Arrow was awake. The dog had heard it too.

I got up to ensure the windows were locked. Outside, a gentle wind stirred the mango tree’s canopy. A distant streetlight flickered on and off like a lighthouse beacon.

J. groaned and rolled over. “What is it?”

“I heard something.”

Arrow growled, jumped off the bed, and began sniffing along the baseboards, moving the length of the room. When he galloped down the stairs, J. and I dutifully followed.

Arrow stood by the back door, ears up, eyes on us. Everything was just as we’d left it. Everything was silent—until it wasn’t. A scraping so violent it made my fingernails ache issued from a corner of the dining room. Afraid of scaring whatever it was away, J. eased open the back door, and the two of us stepped outside.

Frogs chirruped. Something—a bird, a fish, a single, lonesome alligator—shattered the glassy black surface of the pond. J. ran a flashlight over the siding, the eaves, the roof. Nothing.

“It’s already inside,” he said.

“Squirrels?”

“Maybe.” He sounded unconvinced.

“Not squirrels,” said the pest-control specialist who came later that morning, after J. had left for work. Squirrels are daytime animals, he explained. They sleep at night.

I hoped he would say opossum. I hoped he would say, even, raccoon. Either would have been inconvenient and unpleasant but more easily remedied—a Havahart trap, a relocation to a nearby nature preserve, a single hole to fill. Instead he said exactly what I didn’t want to hear.

In the Chinese zodiac, people born in the Year of the Rat are shrewd, fickle, creative, thrifty, and wise. They are a litter of cowardly, hot-tempered, picky musicians, entrepreneurs, lawyers, and writers. They may be plagued by a weak constitution and prone to head colds and other viruses. I was born in the Year of the Rat and, coincidentally or not, possess many of these characteristics. Though I’ve always considered myself hardy, my partial hearing loss—the cause of which doctors were yet unable to explain—suggested otherwise.

Each year of the Chinese zodiac has a corresponding element. Mine is water, which makes me a water rat. Water is an element of hiding and suggests an inability to choose something and stick to it. At times I’ve been true to my watery nature, having been accused of being unable to commit to a job, a person, a responsibility. My initial ambivalence about moving to Florida supported such accusations, and buying a house with J. was my attempt to act against type.

Still, I hadn’t counted on real, live rats. “I’m surprised you hadn’t heard them before,” said Rat Guy #1, as he came to be known. “From the looks of it they’ve been here a while.” He wore a utility belt below a belly like unproofed bread dough. As he walked, his belt jangled with keys, flashlight, laser pointer, measuring tape, Swiss Army knife. He sweated beyond what was socially acceptable, even by Florida standards.

I hadn’t heard them before, but it turned out other people had. J. confessed to noting some rustling when he’d been up late a few weeks earlier. And my brother said he’d heard something when he and my sister-in-law had stayed overnight. Earlier in my life I might have been surprised, angry even, to learn they’d withheld the truth, but by then I’d come to believe it was human nature to look away, to plead ignorance. That was precisely what I’d done for months when my ear had begun to alert me, persistently, that there was a problem.

“I’ll close up the entry points,” said Rat Guy #1. “Set traps, fog the attic.” The fogging, he assured me, was safe for humans and canines—so safe, in fact, that it wouldn’t even kill the rats. Instead it left behind a perfume they found intolerable, driving them away.

This was my introduction to the pest-control business, and over the next several months I discovered that exterminators each have their own predilections, their preferred baits and traps, their brands of flashlights and trash bags in which to dispose of their prey. I also learned that, along with sound machines promising to transmit high-frequency pitches detected only by vermin, fogging is a scam.

Criminal or immoral tricksters are called “dirty rats” or “rat finks,” but Rat Guy #1 didn’t strike me as either of these. For one of what would be many visits, he arrived with his octogenarian mother who had been “bored outta my gourd” and “wanted a look-about.” Our generally discriminating dog loved him. When his truck appeared in the driveway, Arrow wailed at the front door, anxious to be let outside to spastically run circles around the man with an excitement he rarely demonstrated for anyone else, including J. or me. This was the most persuasive argument in favor of trusting Rat Guy #1.

by Lenore Myka, The Sun |  Read more:
Image: © Doug McMains
[ed. I had a rat problem in my last house. The constant rustling in the walls drove me crazy, day and night. After setting traps in the attic, I'd remove on average one, sometimes two dead ones every other day. They kept coming until I finally found their entry point - a small crack in the foundation the size of a quarter. I'd skipped it before because it just didn't look like something a rat could squeeze through. But that was it, and I eventually got them under control after barricading their front door. My friend Jerry in Texas had an even bigger problem. I forget if it was a warning light that kept turning on and off, or a hose leak or whatever, but the problems kept escalating until he finally took his car into the shop to have it checked out. That's when they discovered that a rat family had built a nest up inside the car frame, just behind the gas tank. Apparently they'd been there a long time, as evidenced by all the chewed wires, hoses, and other debris they found. The funny thing is that during the previous month or two after he'd started noticing these problems he'd driven over 700 miles between various states, many on bumpy, dusty backroads. Hard to imagine what that must have felt like for those guys, burrowed way up there in the undercarriage. Tough, scrappy little animals.]

Tuesday, June 23, 2026

June 23, 1988: James Hansen Testified to Senate About Climate Change

Coal is the single greatest threat to civilization and all life on our planet. . . . the dirtiest trick that governments play on their citizens is that they are working for ‘clean coal.’ . . .The trains carrying coal to power plants are death trains. Coal-fired power plants are factories of death. — James Hansen
On June 23, 1988, NASA scientist James Hansen testified to the U.S. Senate stating the greenhouse effect had been detected, indicating that the climate was in fact changing.

Hansen was also arrested on this day in 2009 during a protest against mountaintop removal mining at Massey Energy Company.

Hansen has stated,
Several times in Earth’s long history rapid global warming of several degrees occurred. . . In each case more than half of plant and animal species went extinct. New species came into being over tens and hundreds of thousands of years. But these are time scales and generations that we cannot imagine. If we drive our fellow species to extinction we will leave a far more desolate planet for our descendants than the world that we inherited from our elders.
by Zinn Education Project |  Read more:
Image: uncredited
[ed.  "According to science historian Spencer R. Weart, Hansen's testimony increased public awareness of climate change. According to Richard Besel of California Polytechnic State University, Hansen's testimony "was an important turning point in the history of global climate change." According to Timothy M. O'Donnell of the University of Mary Washington, Hansen's testimony was "pivotal," "ignited public discussion of global warming and moved the controversy from a largely scientific discussion to a full blown science policy debate," and marked "the official beginning of the global warming policy debate." According to Roger A. Pielke of the National Center for Atmospheric Research, Hansen's "call to action" "elevated the subject of global warming and the specter of associated impacts such as more hurricanes, floods, and heat waves, to unprecedented levels of attention from the public, media, and policy makers." - Wikipedia.]

[ed. Which was all it took for climate change skeptics to spring into action, and here we are...]

Monday, June 22, 2026

AI in Biology

If you wind your way through a quiet, wooded suburb outside of The City, you’ll reach a harbor. Situated on a hill overlooking the water, there is a Temple of Science. This Temple is centered around a task of the utmost importance: preserving a magical thread that connects the past, present, and future of the life sciences.

On one end, there is a gentle tug from the ghosts of Barbara McClintock, Martha Chase, and Alfred Hershey, reminding you of their elegant experiments that became part of the canon of genetics. Farther along, figures like Jim Watson grip the thread more fervently as they advocate for the centrality of their discoveries in the birth of molecular biology. If you put one hand in front of the other and continue to follow where it takes you, you’ll pass through the rise of genomics and end up on the frontier of biology.

Of course, I’m talking about Cold Spring Harbor Laboratory. For over one hundred years, this little research institute in Long Island, New York has punched well above its weight. CSHL played a critical role in multiple paradigm shifts in biology—including genetics, molecular biology, and genomics—as evidenced by the eight Nobel Prizes awarded to researchers from “The Lab” over the years. When normalizing for size, the Nature Index ranked CSHL as the most prolific biomedical research institution in the world.

I’ll never forget my first visit to The Lab. In February of 2020, I flew from Seattle to interview for the CSHL graduate school program. Famously (among researchers on the grad school interview circuit), they would arrange for each recruit to be picked up in a black car from the airport.

The campus itself, which is a direct physical representation of the magical thread that The Lab preserves, is equally memorable. A cluster of pristinely maintained colonial buildings, each painted white, borders the water. Above them is the Upper Campus, consisting of darker, modern renditions of the same pattern. Scientific art installations—like the Waltz of the Polypeptides or a gazebo with a phage structure on the tip—can be found along the walking trails.

Over the course of three days, I hurried around The Lab for a wide range of activities, including eleven interviews with faculty—two to three times the number that most other graduate school programs typically scheduled. It was wonderful and intense.

Ultimately, I was persuaded to go west for graduate school. Thankfully, there are many reasons to continue coming back to CSHL, which has been described as “the crossroads of biology.” Each year, they host dozens of conferences and courses that draw top researchers from around the world.

But one particular conference stands out in importance. Since 1933, CSHL has hosted an annual Symposium on Quantitative Biology. Reginald Harris, who conceived of the conference, wrote that the “primary motive of the conference symposia is to consider a given biological problem from its chemical, physical and mathematical, as well as from its biological aspects.” In retrospect, this was visionary.

Over the next several decades, chemists and physicists would revolutionize the life sciences. In 1944, Erwin Schrödinger, a leading physicist, wrote What is Life?, a book exploring open questions in biology through a new lens. It inspired many researchers and students, including a young James Watson, to pursue biological research. In 1953, at the 20th annual CSHL Symposium, Watson presented the structure of DNA for the first time in public.

For obvious reasons, this gave the CSHL Symposia a sort of “mythic quality” moving forward. This reputation compounded quickly. Over the next 15 years, the pioneers of molecular genetics would travel each year to present their most important discoveries—such as the central dogma and the genetic code—at CSHL.

The tradition continues to this day. Each year, the Symposium is organized around a topic considered to represent the frontier of life sciences research.

Which brings us to the topic of the 90th Cold Spring Harbor Laboratory Symposium on Quantitative Biology: AI in Biology.

Readers of this newsletter are not strangers to the fact that AI is reshaping biology. The tools derived from breakthroughs such as AlphaFold have been adopted by seemingly all biologists at this point. But it was stunning to see these advances celebrated so prominently in this venue. It felt historical.

As Bruce Stillman, CSHL’s current President, pointed out in his opening remarks, this topic connects back to the very origin of the Symposia—as the name suggests. Harris had spotted the emergence of a new quantitative paradigm in biology. Between then and now, molecular genetics did in fact transform biology into an information science.

It’s becoming more clear each day that the next chapter of this story is AI. Sydney Brenner, one of the most central figures of molecular biology, gave one of the most incisive criticisms of the field in his Nobel Prize lecture: “We’re drowning in a sea of data and starving for knowledge.” AI is starting to change that equation.

For five days, top researchers in the field shared updates on their efforts to use machine learning to decipher the mechanisms of DNA, RNA, proteins, cells, tissues, organs (especially the brain), and how information flows between these different biological scales. And there were examples of how AI agents might be able to autonomously carry out some of this research—which was met with a combination of excitement and anxiety from attendees.

It was one of the most compelling conferences I’ve ever attended, so I want to share some of what I saw. Before jumping in, this requires a few quick notes on the format of the event.

First, attending a Symposium feels like drinking from a scientific firehose—by design. CSHL is truly a Temple, or maybe even a monastery. Most attendees stay on campus and don’t leave for the duration of the conference. Talks are back-to-back all day in the main auditorium, followed by communal meals and poster sessions that run throughout the evening. It’s non-stop. My goal isn’t to give an exhaustive blow-by-blow, but to highlight some of the themes and topics I found most exciting.

Second, following in the tradition of Watson, many researchers share more new and unpublished data than is typical at other conferences. To respect this tradition, I’m going to focus on the data shared that has already been published, with more high-level descriptions of new research directions and results.

With all that said, let’s get into it! [...]

Agents, Agents, Agents

Maybe I’m in a bubble in San Francisco, but it’s hard not to constantly hear about AI agents in the year 2026. It’s strange to think, but it’s been three and a half years since ChatGPT was first released. That’s long enough for many humans to feel frustrated by the shortcomings of what was once magic. Now, we want these models to do work for us, and to carry out longer, more complex projects that require reasoning.

There are now many efforts to develop systems for “agentic science,” where AI models are able to autonomously develop new hypotheses, design experiments, and analyze results. This concept was another recurring theme at the symposium.

Pushmeet Kohli hit on this the first evening. The last third of his talk focused on DeepMind’s efforts to build an AI Co-Scientist, which they published a new paper on last month. Given a research goal by a human scientist, this system develops a research plan and then kicks off a “tournament” of agents competing to develop new hypotheses. Agents within this system have different tasks. Some are designed to “reflect” on the ideas being generated. Others are tasked with “evolving” them.

While the goal is hypothesis generation, the AI Co-Scientist itself is no longer just a hypothetical. DeepMind has already given early access to academic researchers working in a wide variety of biomedical domains. Kohli highlighted a high profile example where the Co-Scientist was able to predict a new mechanism of bacterial gene transfer before the result was published in the literature.

by Elliot Hershberg, The Century of Biology | Read more:
Image: uncredited/CSHL
[ed. See also: What’s new in biology: June 2026 (Works in Progress).]

Sunday, June 14, 2026

The Last Great Wilderness

Ping-pong sponges, ‘black smokers’ and floating somethings: the secrets of the deep sea.

If you want to follow in the footsteps of the great explorers, forget the moon and Mars: the ocean floor is where the real action is. The deep ocean, the part that’s deeper than 200 metres, covers about 66% of the Earth’s surface. Most of it has never been surveyed in detail. Even less has been seen up close. If the current rate of observation continues, a complete visual survey of the ocean floor will take about 5m years. [...]

The deep ocean is the largest ecosystem on Earth. It is also in many ways the most extreme, home to crushing pressures, extremes of heat and cold, and a near total absence of sunlight. Animals inhabiting this midnight world tend to be equally extreme. It is a menagerie that abounds in superlatives: the largest, the oldest, the blackest, the most luminous. But those are only the ones we know about. Most of the animals dwelling in the benthos, the true deep, remain unknown to science. Virtually every scientific expedition to reach this zone of darkness returns with new species in tow. In the past year, scientists have discovered more than 1,100 new marine species. Among them are a ghost shark (not really a shark), a ping-pong ball sponge (which does look like a cluster of ping-pong balls), a number of luridly coloured worms and a floating something that resembles a tiny jet plane made out of pale pink jelly, and which scientists have not yet been able fit into any of the primary categories of animal life. [...]

For over 50 years, would-be industrialists and entrepreneurs have floated the idea of mining the ocean floor, but without much happening in practice. But in our search for new sources of metals needed for batteries and microchips, we may now be on the cusp of destroying the world’s largest – and strangest – ecosystem before we get a chance to understand it.

by Jacob Mikanowski, The Guardian | Read more:
Images: Jim Maragos/AP; Nekton Ocean Census/Schmidt Ocean Institute

Friday, June 5, 2026

In Support of Mandatory Nucleic Acid Synthesis Screening and Recordkeeping

As life sciences researchers, builders of AI and biotechnology, and experts with a wide range of views on how to approach AI policy, we call on legislators to make screening of orders for synthetic nucleic acids — and the equipment needed to make them — mandatory.

The ability to order synthetic DNA online has accelerated vaccine development, powered basic research, and made it possible for small teams to access capabilities that used to be confined to major institutions. Since the publication of protocols to reconstruct viruses from strands of DNA more than two decades ago, it has also been recognized as a point in the biotechnology supply chain where a bad actor could cause outsized harm. Recognizing the vulnerability, synthesis companies formed the International Gene Synthesis Consortium in 2009 to develop and implement voluntary safeguards against misuse.

While the issue is not new, the pace of progress in artificial intelligence is. AI systems now outperform PhD-level virologists on questions about highly technical laboratory procedures in their own domains of expertise. The evidence about what this means for present-day biosecurity threats is genuinely mixed, but the trend is hard to dispute. AI systems are improving rapidly, and alongside incredible benefits to science and medicine, there is a real possibility that the knowledge barriers which have historically prevented bad actors from obtaining biological weapons will meaningfully erode.

Support for screening does not depend on any particular view of AI; the biosecurity case has been recognized by scientists and governments for decades. Screening is also one of the best understood and least disruptive biosecurity measures available. It asks providers of synthesized DNA and manufacturers of synthesis machines to check synthesis requests for sequences of concern and to verify customer legitimacy before shipping orders. Providers should also record synthesis orders and sequence data to support legitimate biosecurity investigations, so that any threat that might evade initial screening can be traced back to its source — including when individual sequences would not raise concern in isolation. Awareness of traceability itself deters misuse.

Many of the largest and most responsible providers in the industry already screen and record orders voluntarily because it is well understood that they have an important role to play in maintaining public trust in and mitigating potential misuse of this important technology.

For these reasons, the undersigned support mandatory nucleic acid synthesis screening, including recordkeeping, in the United States.

Given the pace at which the underlying technology is changing, we believe the need is urgent. Congress should act this session, and we applaud the legislative efforts currently underway. To ensure a consistent national standard rather than a patchwork of conflicting laws, states should also consider implementing requirements based on existing federal and industry guidelines.

This is a rare moment of agreement across stakeholders that are often at odds. We hope policymakers will meet it with decisive action.

Sincerely,
Signatories: — *Everybody*
[ed. No brainer, right? You don't just leave potential life-threatening bio-warfare components laying around with no oversight. Right?]
***
Amrith Ramkumar (WSJ): Top artificial-intelligence executives are joining security experts in calling for Congress to protect against biological threats posed by AI, adding to growing pressure on lawmakers to address the technology’s risks.

Three major chief executive officers—OpenAI’s Sam Altman, Anthropic’s Dario Amodei and Demis Hassabis of Google’s DeepMind AI lab—are among the signatories of a letter urging Congress to require safeguards when companies order synthetic DNA and RNA, a key step in developing certain vaccines and biotech breakthroughs.

… It was organized by two tech-focused think tanks that said the topic is a rare source of agreement among libertarians, progressives, researchers and rival executives.

Dean W. Ball: I am honored to have signed on to this letter. This is an urgent priority for near-term action by Congress. Biotech is advancing rapidly on its own, and I—and many others—believe the “Mythos moment” in AI/bio is coming soon. It is time for action.

revisions to existing nucleic acid screening requirements were mandated by an EO POTUS signed a year ago; I worked on them while in govt. I genuinely don’t know what happened to that work after I left but it is nine months behind schedule. Congress acting is better anyway.

Joshua Teperowski Monrad: People are so astounded when I tell them this isn't already law

Alec Stapp: it really is insane [...]
Other signatories include Patrick Collison, Paul Graham, Mustafa Suleyman, Alexandr Wang and a lot more where that came from.

We need such letters, despite this having ~100% support among those who understand any side of this, this is such a slam dunk that we should be doing this even before considerations of AI making malicious action vastly easier.

Why? Because political awareness is basically still near zero:
Will Poff-Webster: When I was a Senate staffer and occasionally got the chance to bring up biosecurity risks from AI, the response was often, “What? AI might be able to do that?”

This letter shows how easy it’d be for Congress to act on this